Clinical Significance Of AKR1B10 Expression In Hepatocellular Carcinoma And Correlation Analysis Of Clinicopathological Features

Background:Hepatocellular carcinoma is a kind of common malignancy,with characteristics of a high degree of malignancy,rapid progression,and poor prognosis.To improve the therapeutic effect of hepatocellular carcinoma is still a serious medical problem to be solved.The aldo-keto reductase superfamily is a group of proteins with important functions,and AKR1B10(aldo-keto reductase family 1 member B10)is a member of this superfamily.It has been reported that AKR1B10 is upregulated in many types of solid tumors,such as hepatocellular carcinoma and thyroid papillary carcinoma,suggesting that it may exert an oncogene effect,while the mTOR(mammalian target of rapamycin)kinase inhibitor CZ415 plays a suppressive role in hepatocellular carcinoma and thyroid papillary carcinoma.The study found that AKR1B10 may be involved in hepatocarcinogenesis.This article will investigate the relationship between the expression of AKR1B10 and the prognosis of patients with hepatocellular carcinoma.Objective:To define the expression of AKR1B10 in hepatocellular carcinoma;To analyze the clinical significance of AKR1B10 expression in hepatocellular carcinoma;To explore the value of AKR1B10 in evaluating the prognosis of postoperative patients with hepatocellular carcinoma.Methods:Collect the cancer tissue,paired adjacent tissues,and histological sections of 107 patients with hepatocellular carcinoma undergoing radical hepatectomy from May 2009 to April 2011 in Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,detect the expression of AKR1B10 in hepatocellular carcinoma by immunohistochemistry,analyze the relationship between AKR1B10,the clinicopathological data and prognosis in patients with hepatocellular carcinoma.The clinical pathological data of patients mainly includes:age,gender,HBV infection status,cirrhosis,ascites,AFP,ALT,LDH,blood glucose,number of tumors,tumor size,tumor capsule,satellite lesions,portal vein tumor thrombus,T-stage,pTNM-stage,tumor differentiation.Data processing was performed using SPSS 17.0 statistical software package for statistical analysis.Results:1.The expression level of AKR1B10 in hepatocellular carcinoma tissues was significantly higher than that in paired adjacent tissues(P<0.001).2.LDH(P=0.009),tumor size(P<0.001),presence of satellite lesions(P<0.001),presence of portal vein tumor thrombus(P<0.001),T-stage(P=0.031),pTNM-stage(P=0.001)and AKR1B10 expression levels(P=0.003)corresponding to the overall survival of patients with hepatocellular carcinoma were statistically significant(P<0.05)which is an important risk factor affecting the prognosis of patients with hepatocellular carcinoma.3.The overall survival of hepatocellular carcinoma patients with AKR1B10 expression levels(P=0.002)and satellite lesions(P=0.024)was statistically significant(P<0.05)and they were independent risk factors for the prognosis of patients with hepatocellular carcinoma.Conclusions:AKR1B10 is highly expressed in hepatocellular carcinoma,and the prognosis of patients with high expression is poor.Multivariate analysis showed that AKR1B10 expression levels and the tumors with or without satellite lesions are independent risk factors for prognosis of patients with hepatocellular carcinoma.