| ObjectiveBy observing the dynamic changes of TCM syndrome elements at different time points in patients with TIA/minor stroke and its correlation with their short-term prognosis,the possible TCM syndrome features that may affect the recurrence of stroke will be explored so as to guide the early clinical analysis of TCM syndromes to assist in judging the short-term prognosis of patients with non-disabling ischemic cerebrovascular disease.MethodsA total of 201 patients with TIA/minor stroke admitted within one week in Cerebropathy Center of the First Affiliated Hospital of Guangzhou University of Chinese Medicine from October 1st,2016 to August 31th,2017 were enrolled in this study.According to the telephone follow-up after 90 days,patients were divided into the recurrent group(n=31)and control group(n=170).The first part of the collection recorded the general clinical data of patients admitted to hospital,including gender,age,underlying disease,tobacco and alcohol history,biochemical indicators,NIHSS score.The second part was based on the four diagnostic information of TCM,and recorded the TCM syndrome elements in the three time points of admission(Tl),48 hours(T2)and admission of the 10th day(T3).The third section documented the smRSq score for the 90-day telephone follow-up.All the above information and data were analyzed statistically using SPSS22.0 statistical package.Result1.The 201 patients with TIA/minor stroke(NIHSS?5 points)were included in this study.Recurrence group 90-day life dependence and disability rates were significantly higher than the control group(P<0.05).2.The main TCM syndromes of TIA/minor stroke patients were mainly the excess and most combinations contained 2-3 kinds of syndrome elements.The most prominent was the internal wind and the proportion decreased significantly as the condition changed.Qi deficiency showed a clear upward trend at the same time.The proportion of phlegm-damp and blood stasis syndrome at each time point changed slightly.But the proportion of phlegm syndrome was higher than the blood stasis syndrome.Qi deficiency,yin deficiency,blood stasis and phlegm-damp syndrome were mainly the syndrome distributions in the later stages of patients with TIA/minor stroke.Syndromes manifested as deficiency or deficiency and excess syndrome mixed.Most of the combinations tended to be more single than the early onset,with combinations of 1-2 kinds of syndromes.3.Based on the results of association rules,we could find that the phlegin-damp and blood stasis syndrome of TIA/rminor stroke patients weren^t easy to change.4.As for the patients of TIA/minor stroke with admission within 48 hours(T2)of internal fire or late onset(T3)of internal fire or the interna.l wind,the risk of stroke recurrence was significantly higher and the prognosis of 9O-day functional outcomes was poorer(P<0.01).5.In addition,the early onset of internal fire and blood stasis syndrome may be related to the history of previous TIA/minor stroke(P<0.01).Conclusion1.The 90-day functional outcomes of TIA/ininor stroke patients are not optimistic,especially in patients with recurrent stroke;2.The overall distribution of TCM syndromes in the acute phase of TIA/minor stroke patients is basically consistent with the previous studies;3.The clinical should pay attention to the changes of the internal fire and internal wind syndrome of TIA/minor stroke patients during hospitalization,especially in the later stage of disease stabilization,the identification of internal wind and internal fire syndromes reappeared;4.It is necessary to grasp the characteristics of TCM syndrome elements for TIA/minor stroke in order to achieve individualized risk assessment of TCM,which has practical clinical significance for promoting prevention and treatment under the guidance of"disease-intensity combination" of stroke disease. |
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