The Effect Of Natriuretic Peptide On Cardiac Function In Patients With Acute Extensive Anterior Wall ST Elevation Myocardial Infarction After Emergency Percutaneous Coronary Intervention

Objective: To analyze the effect of recombinant human brain natriuretic Peptide(rh BNP)on cardiac function and short-term(3 months)prognosis of patients with acute extensive anterior ST-segment elevation myocardial infarction after emergency percutaneous coronary intervention(PCI),so as to improve the prognosis of patients with acute extensive anterior ST-segment elevation.Therapeutic effect and prognosis recovery of patients with high myocardial infarction can provide reference.Method: A total of 80 patients with acute extensive anterior ST-segment elevation myocardial infarction who underwent emergency percutaneous coronary intervention(PCI)in our hospital(Jinzhou First People’s Hospital)from January 2015 to January 2017 were selected strictly according to the inclusion and exclusion criteria.They were divided into control group(40 cases)and observation group(40 cases).The basic situation of the two groups before treatment was similar(P > 0.05).Patients in the control group were treated with routine secondary preventive drug therapy for coronary heart disease after emergency percutaneous coronary intervention(PCI);patients in the observation group were treated with early combination of neovaxin(recombinant human brain natriuretic peptide)for 72 hours on the basis of the above treatment.The changes of cardiac index data within 72 hours after operation and the heart at 3 months after operation were compared between the two groups.The difference of the index data of dirty color Doppler ultrasonography.Result:(1)Before treatment,there was no significant difference in the baseline data and clinical characteristics between the two groups,P > 0.05,with no statistical significance.(2)After 24,48,72 hours and 3 months follow-up,the blood NT-pro BNP level of the patients in the observation group was significantly lower than that of the patients in the control group,and there were significant differences in each value,P < 0.05,with statistical significance.(3)At 72 hours after operation,the left ventricular ejection fraction,left ventricular end-diastolic diameter and cardiac function index of the two groups were significantly better than those of the control group,with significant differences(P < 0.05),with statistical significance.(4)At 3 months after operation,the left ventricular ejection fraction in the observation group was(51.72±6.28)% and that in the control group was(45.27±5.28)%.There was a significant difference in the left ventricular ejection fraction between the two groups(P < 0.05).(5)At 3 months after operation,the left ventricular end-diastolic diameter of the observation group was 48.56±3.71 and that of the control group was 52.35±3.14.There was significant difference between the two groups(P < 0.05).(6)At 3 months after operation,the cardiac function index of the observation group and the control group were 3.51 ± 0.78 and 3.05 ± 0.53,respectively.There was significant difference in the cardiac function index between the two groups(P < 0.05).(7)At 3 months after operation,the improvement of cardiac color Doppler ultrasound in the observation group was better than that in the control group 72 hours after operation,P < 0.05,with statistical significance.(8)Within 3 months after operation,the incidence of adverse cardiac events in the observation group and the control group were 7.5% and 20%,respectively.There were significant differences in the incidence of adverse cardiac events between the two groups,P < 0.05,with statistical significance.Conclusion: Patients with acute extensive anterior ST-segment elevation myocardial infarction treated with emergency percutaneous coronary intervention(PCI)were treated with recombinant human brain natriuretic peptide(rh BNP)early after operation(for 72 hours).The cardiac output increased significantly within 3 months after operation,and the condition of myocardial remodeling improved significantly,which was conducive to the recovery of cardiac function and delayed the deterioration of cardiac function.At the same time,it can effectively reduce the incidence of adverse cardiovascular events after PCI,which has a positive significance for the overall prognosis of acute extensive anterior ST-segment elevation myocardial infarction.