| Objective: To observe the clinical efficacy and safety of Jiawei Xiaoyao Powder in the treatment of functional constipation(FC)liver qi stagnation syndrome,and to summarize the clinical experience of Professor Liguixian in the treatment of FC,and to explore the diagnosis and treatment of this disease.Methods: This topic is divided into two parts: systematically summarizing Professor Liguixian's clinical experience in the treatment of FC and the experience of the instructor Fang Jiawei Xiaoyao San in the treatment of FC.(1)Summary of experience: Through clinical study,copying,notes,lectures,case discussions,regular review and refinement of clinical experience,summarizing the clinical and academic experience of the instructor's treatment of FC.(2)Clinical study: 86 patients with liver qi stagnation syndrome who met the study criteria were randomly divided into treatment group and control group,43 cases each.The treatment group was given Jiawei Xiaoyao Powder,and the control group was given lactulose oral solution for 4 weeks.The clinical symptoms,anorectal manometry and quality of life of the two groups were observed before and after treatment,and the prognosis was evaluated.Statistical software for analysis.Results: A total of 5 cases were absent during the experiment,and 41 cases were observed in the control group and 40 cases in the treatment group.(1)Comparison of clinical symptoms: The total effective rate was 92.5%and 75.6%,respectively,and the treatment group was higher than the control group(P<0.05).(2)Comparison of clinical symptom scores:(1)Main symptom scores:The main symptoms of each group were better than those before treatment(P<0.05).After treatment,the symptoms of defecation time were better than that of the treatment group.The frequency of defecation,difficulty in defecation,abdominal distension and abdominal pain were better than those in the control group.There was no significant difference in fecal traits and defecation(P > 0.05).(2)secondary symptom scores: single secondary symptoms,except for the control group,the intestinal suffocation,fatigue and too much treatment were not obvious after treatment(P > 0.05),the two groups of hernia hiccups,eating less,staying,chest fullness,feelings Abnormal symptoms were significantly improved(P < 0.05),and the treatment group was superior to the control group(P<0.05).(3)Total score:The treatment group was lower than the control group(P<0.01).(3)Comparison of anorectal manometry: There was no significant difference between rectal rest and anal canal pressure before and after treatment(P > 0.05).The maximum anal canal pressure,rectal defecation pressure and anal relaxation rate in the treatment group Compared with before treatment,the initial sensory threshold,initial defecation threshold,defecation urgency threshold,and maximum tolerated capacity were significantly lower than before treatment(P < 0.05).In addition to rectal defecation pressure,defecation threshold,anal relaxation rate There was no significant difference,the maximum contraction pressure of the anal canal increased significantly,and the initial sensory threshold,initial defecation threshold,and maximum tolerated capacity decreased compared with before treatment(P<0.05).After treatment,the maximum angioplasty pressure,rectal defecation pressure,defecation urgency,and anal relaxation rate were significantly better in the treatment group than in the control group(P<0.05).(4)Comparison of the classification of the two groups: There was no significant difference in the number of FC classification between the two groups(P>0.05).(5)Comparison of quality of life: The quality of life of the two groups of patients improved significantly after treatment,and the physiological status,psychological state,anxiety,satisfaction and total score were significantly reduced(P<0.05).In the control group.(6)Comparison of safety and recurrence rate: There was no obvious adverse reaction in the treatment of the two groups.After 4 weeks of follow-up,the recurrence rate of the treatment group was 14.7%,and the recurrence rate of the control group was 37.9%.The recurrence rate of the treatment group was significantly lower than that of the control group.Group(P<0.05).Conclusion:(1)Instructor treatment FC attaches importance to the four-diagnosis,combined with disease and syndrome,to soothe the liver and strengthen the spleen,and to adjust the air-conditioner as a method,with both qi and stomach,kidney and lung,and bowel laxative.Jiawei Xiaoyao San is one of the representative parties that coordinate liver spleen and air,regulate liver and spleen qi and blood,and relieve turbidity.It is the embodiment of Professor Liguixian's academic thoughts of using Familiar Xiaoyao Powder to treat FC.(2)Jiawei Xiaoyao Powder is a clear and sufficient theory for the treatment of FC liver qi stagnation syndrome,which is superior to the control group in relieving clinical symptoms,improving rectal perception threshold,rectal sensitivity,enhancing muscle contraction function and improving quality of life.Effective,worthy of further promotion and research. |
PDF Full Text Request