Study On Acupoint Sensitization Of Patients With Intestinal Diseases Based On Graph Theory

Objective:To explore the law and distribution characteristics of acupoint sensitization among the diarrhea type irritable bowel syndrome patients with meridian theory and graph theory.To assist the acupuncture clinical diagnosis of diarrhea type irritable bowel syndrome and provide reference for its curative effect evaluation,for further understanding of acupoint sensitization in clinical practice.Methods:Achieve the name of acupoints and their indications of diseases in the classic books of acupuncture and moxibustion for mathematical modeling.Establish the acupoint-symptom network based on graph theory and record the topological parameters such as clustering coefficient,vector centrality,etc.For the clinical trial part,adopt the method of cohort study to include the patients that meet the diagnostic criteria of diarrheal irritable bowel syndrome as the observation objects,measure the acupoint sensitivity data through body meridian energy system.The acupoint sensitivity value of healthy subjects was taken as the control,and the basic information as well as disease-related information of the enrolled subjects were collected.Analyze the occurrence law of electro-sensitization at the original point in patients with diarrheal irritable bowel syndrome with SPSS 20.0.Obtain the topological indexes by mathematical modeling and calculate the weighted average of topological parameters of the Yuan point,so as to further analyze its correlation with the disease and then to compare with the traditional analysis result.Results:1.Acupoint-symptom complex networks of acupuncture and moxibustion classic books all show "small world effect",among which acupoint nodes' close centrality and feature vector centrality indexes present acupoint specificity,which can be used as index for weighted average algorithm;2.The original point resistivity abnormality rate of patients with diarrhea irritable bowel syndrome was 40.71%,and that of healthy subjects was 29.49%(p=0.002).The resistance of patients with irritable bowel syndrome was higher than that of healthy subjects(p=0.019).3.Based on the weighted average algorithm of intermediary centrality or eigenvector centrality,the weighted average of topological parameters of primary point resistance in patients with diarrhea irritable bowel syndrome was higher than that of healthy subjects,with p values of 0.032 and 0.046,respectively.Conclusion:1.Having "small-world effect" may be one of the topological characteristics of acupoint-symptom complex network;2.The increase of skin primary point resistance in patients with IBS-D is a manifestation of acupoint sensitization;3.Acupoint Hegu(LI4)sensitization on behalf of the large intestine meridian is one of the specific manifestations of primary acupoint sensitization in patients with diarrhea irritable bowel syndrome;4.The weighted average algorithm based on Eigenvector Centrality of original acupoint feature vectors can better reflect the overall difference between patients and healthy people through Yuan acupoints;5.It is a feasible attempt to study and express the law of acupoint sensitization based on graph theory.