Application Of Asymptomatic Leukoaraiosis Patients:Based On Arterial Spin Labeling Imaging

Objective:Using 3.0T magnetic resonance arterial spin labeling(ASL)technique,we explored the correlation between cerebral blood flow(CBF)and the severity of Leukoaraiosis(LA)in 116 brain regions of asymptomatic leukoaraiosis patients.Methods:From January 2017 to December 2018,41 asymptomatic leukoaraiosis patients were treated in the Department of Neurology,SuBei Hospital.1.To collect baseline data,such as gender and age;2.All subjects were assessed by Mini-Mental State Examination(MMSE);3.All subjects underwent magnetic resonance imaging(MRI)and measured the relative blood flow in 116 brain regions quantitatively by using 3D-ASL technology;4.Fazekas white matter scale was used to evaluate the periventricular and deep white matter lesions.The total score was divided into mild LA and moderate LA;5.CBF values of 116 brain regions were obtained by MRICRON post-processing software;6.Matched t test was used to analyze the correlation of data.Results:1.There was no statistical difference in baseline data.2.CBF in 116 brain regions decreased in mild LA and moderate LA.Compared with mild WML,the decrease of cerebral blood flow perfusion was more obvious in moderate to severe WML patients.3.Cerebral blood flow was correlated with the grade of leukoaraiosis.Mild LA was significantly different from moderate to severe LA in bilateral infratemporal gyrus,parietal gyrus,occipital lobe,hippocampus,parahippocampal gyrus,cerebellum and vermis.Conclusions:1.ASL parameters can observe 116 cerebral perfusion blood flow changes;2.Asymptomatic leukoaraiosis patients have local cerebral blood flow decline,and the degree of decline is related to the severity of leukoaraiosis,which may become a neuroimaging marker for detection and progress monitoring in the future.