Clinical Study On Peripheral Blood Inflammatory Markers And Blood Lipid Levels In Patients With Parkinson's Disease

Objective: By investigating high-sensitivity C-reactive protein(hs-CRP),neutr ophil-to-lymphocyte ratio(NLR),interleukin-6(IL-6),tumor necrosis factor alpha(TNF-alpha),and lipid levels in Parkinson's disease(PD)changes in peripheral bl ood of patients,and the differences and clinical relevance of the above indicators in different clinical classifications of PD,looking for blood markers that can predi ct PD progression,providing a theoretical basis for anti-inflammatory therapy and lipid-lowering therapy of PD.Methods: 61 patients with primary PD were selecte d as the case group,and 61 healthy subjects were selected as the control group.According to H-Y staging,UPDRSIII score,education level and whether or not le vodopa drugs were used,they were divided into different subgroups.The hs-CRP,NLR,IL-6,TNF-? and blood lipid levels were detected in the case group and th e control group,and the differences and clinical correlations between the above-m entioned indicators between the case group and the control group and the subgrou ps of the case group were analyzed.Results: Serum total cholesterol(TC),high-d ensity lipoprotein-cholesterol(HDL-C),low-density lipoprotein-cholesterol(LDL-C),and apolipoprotein B(apoB)were significantly higher in the case group.P<0.05),hs-CRP,TNF-?,IL-6 levels and NLR values were significantly higher than the c ontrol group(P<0.05);TC,HDL-C,LDL-C,and apoB levels were significantly lo wer in patients with advanced PD.In early patients(P<0.05),the level of hs-CRP was significantly higher than that of early patients(P<0.05).The levels of TG,TC,LDL-C and apoB in PD patients with high education level were significantly higher than those in the lower education level.P<0.05);HDL-C levels in patient s with tremor(TD)PD were significantly lower than those with unstable gait(PI GD)(P<0.05);levodopa and levodopa There was no significant difference in the above indicators between PD patients(both P>0.05).Correlation analysis suggestedthat TC(r=-0.368),LDL-C(r=-0.328),apoA1(r=-0.328),and apoB(r=-0.326)le vels were negatively correlated with HY stage in PD patients(both P <0.05),TN F-?(r=0.297)level was positively correlated with HY stage(P<0.05),TC(r=-0.296),HDL-C(r=-0.304),apoA1(r=-0.343)level Both were negatively correlated wit h UPDRSIII score(P<0.05),hs-CRP(r=0.312)was positively correlated with UPD RSIII score(P<0.05),TC(r=-0.287),LDL-C(r=-0.279).The apoB(r=-0.306)level was negatively correlated with age(P<0.05),and the level of apoB(r=-0.285)wa s negatively correlated with the age of onset(P<0.05).Conclusion: 1.The levels of hs-CRP,IL-6,TNF-? and NLR in peripheral blood of patients with PD increa sed,and the overall level of blood lipids decreased.2.The levels of hs-CRP,TNF-? and blood lipids in peripheral blood of patients with PD may be to some exten t.The severity of PD was different.3.The level of blood lipids in PD patients w as different between different educational levels.The level of HDL-C was differen t among different types of dyskinesia.4.The level of apoB may be related to the pathogenesis of PD.Levodopa drug therapy There is little effect on the inflammat ory response and blood lipid levels in PD patients.