The Fabrication And Research Of Alginate Medical Dressings Via Microfluidic Spinning

At present,the aging of the human society has become more and more obvious.The new medical dressings appeared with that more and more chronic wounds related to the elderly such as acne and ulcers,these wounds are deep,accompanied by exudate usually,and have a long healing period.New type medical dressings which possess moisture absorption and moisturizing properties have attracted the more and more attention of researchers and developers due to the remarkable effect of"wet therapy"in the treatment of wound healing.The traditional medical dressings could not satisfy the conditions required for the care chronic wound.In order to alleviate the suffering of patients and shorten the wound healing cycle,the new type medical dressings need to be researched and developed.In this paper,the alginate fibrous dressings that are suitable for the care of chronic wound,which were prepared by microfluidic spinning technology,and their performance characteristics were evaluated comprehensively.Firstly,the calcium alginate fibers were prepared by microfluidic spinning technology,We explored several factors that affect fiber,included the concentration of sodium alginate?Na-Alg?solution and calcium chloride?CaCl₂?solution,the flow rate of Na-Alg and CaCl₂ spinning injection.The experimental results show that the diameter of fibers increased with the increased concentration of Na-Alg solution and the reduced concentration of CaCl₂ solution,and with the increased flow rate of Na-Alg solution and the reduced solution flow rate of CaCl₂.Secondly,a high-water-absorbing calcium alginate fibrous scaffold was fabricated simply by microfluidic spinning and centrifugal reprocessing.And we evaluated its application performance in the field of medical dressing comprehensively.Our results indicate that this material possesses high water-absorbing properties,is biocompatible,and has a 3D structure that mimics the extracellular matrix,while fibers loaded with silver nanoparticles?AgNPs?exhibit broad-spectrum antibacterial activities;these properties meet the requirements for promoting the healing of chronic wounds and are widely applicable to wound dressings.Lastly,Calcium alginate-polyethylene glycol dipropylene ester?PEGDA?fibers were prepared by microfluidic spinning and the Calcium alginate PEGDA injectable fibrous hydrogel were prepared through cut shorted,injected progress.We explored the effect of fibers through the different ratio of Calcium alginate and PEGDA and the swelling properties of Calcium alginate-PEGDA fibrous hydrogels were tested under different conditions at room temperature.The results showed that the diameters of the Calcium alginate-PEGDA fibers decreased with the decrease of sodium alginate content;the swelling rate of the Calcium alginate-PEGDA fibrous hydrogels firstly increased and then decreased with the increase of the PEGDA content;the fibers were arranged in orientation after injection,the orientation would conducive to the migration of cells during wound healing,and expect to accelerate the healing rate of wounds.The high-water-absorbing calcium alginate fibrous scaffold and the Calcium alginate-PEGDA injectable fibrous hydrogel which prepared herein have significant advantages for treating chronic wounds,particularly the wounds with exudate and deeper depth.They could satisfy the requirements of accelerating chronic wound healing and further expand the future application of new type medical dressings.