Clinical Study On The Efect Of Wenshentiaojing Recipe On Serum 1,25-Dihydroxyvitamin D In Patients With PCOS

Objective:To observe the clinical efficacy of Wenshentiaojing Recipe in treating polycystic ovary syndrome（PCOS）and its effect on the level of Serum 1,25-dihydroxyvitamin D,and to explore its mechanism.Methods:Forty cases with syndrome of kidney-yang deficiency（PCOS group）were randomly divided into two groups:20 cases of Wenshentiaojing Recipe（treatment group）and Huan Shao Ting Capsule group（control group）.And 20women（normal group）with normal menstruation,gynecological B-ultrasound and no endocrine abnormalities were selected.To compare the difference of1,25-dihydroxyvitamin D between PCOS group and normal group,and to observe the improvement of TCM clinical syndromes before and after treatment,pregnancy status,and 1,25-dihydroxy vitamin D and changes in estradiol（E₂）,luteinizing hormone（LH）,follicle-stimulating hormone（FSH）,LH/FSH,testosterone（T）,prolactin（PRL）,and insulin（INS）.Results:（1）The serum 1,25-dihydroxyvitamin D value in the PCOS group was significantly lower than that in the normal group（<0.01）;after treatment,serum 1,25-dihydroxyvitamin D values in the treatment group and the control group were significantly higher than those before treatment.Significant difference（<0.01）,there was a significant difference between the groups（<0.05）.（2）There was no significant difference in the three groups of age distribution and the course of treatment,1,25-dihydroxyvitamin D,FSH,E₂,PRL,LH,T,INS between the pretreatment group and the control group（>0.05）.（3）After treatment,t hetreatment group was superior to the control group in terms of efficacy,comprehensive curative effect,and pregnancy status of TCM syndromes;both groups could significantly reduce LH,LH/FSH levels,and differences between groups（<0.01）;The levels of INS and T were decreased in the group（<0.05）;there was no significant difference in the levels of FSH,E₂,and PRL between the two groups（>0.05）.（4）1,25-dihydroxyvitamin D was negatively correlated with LH/FSH,T,INS（<0.05）.Conclusion:（1）Vitamin D in patients with PCOS is significantly insufficient.（2）Wenshentiaojing Recipe can increase vitamin D levels.（3）Wenshentiaojing Recipe can effectively improve TCM syndromes,significantly reduce LH,T,LH/FSH,INS values and regulate reproductive endocrine levels.（4）Wenshentiaojing Recipe treatment of PCOS mechanism of action and improve the patient’s vitamin D levels.