The Correlative Analysis Of TCM Syndrome Types And Objective Indicators In 3-5 Stage Of Chronic Kidney Disease With Secondary Hyperparathyroidism

Objectives: The distribution pattern of TCM syndromes in chronic kidney disease(CKD)3-5 stage combined with secondary hyperparathyroidism(SHPT)was studied,and the correlation between TCM syndrome Types and objective indicators was provided.It provides a new reference basis for understanding and treating this disease from the perspective of traditional Chinese medicine.Methods:Collect 115 cases of stage 3-5 chronic kidney disease complicated with secondary hyperparathyroidism in patients with age,sex,CKD stage,primary disease,concomitant disease and other basic clinical data and serum creatinine(SCR),uric acid(UA),urea nitrogen(BUN),parathyroid hormone(PTH),serum calcium(Ca),serum phosphorus(P),carbon dioxide combining power(CO2CP),hemoglobin(Hb),and other laboratory indexes and symptoms and signs,tongue and pulse,in stage 3-5 chronic kidney disease with secondary hyperparathyroidism clinical information questionnaire.The statistical method was used to analyze the distribution of TCM Syndrome Types in 3-5 stages of chronic kidney disease with secondary hyperparathyroidism and the correlation between the TCM syndrome types and the objective indicators.Result:1.Distribution law of TCM syndrome types1.1 The distribution of deficiency syndrome: the spleen kidney yang deficiency syndrome is most seen,and the rest from high to low is liver kidney yin deficiency syndrome,spleen kidney qi deficiency syndrome,Qi Yin two deficiency syndrome,yin and yang two deficiency syndrome.There was no statistical difference between the deficiency syndrome and the sex and age(P>0.05),and there was a statistical difference from the CKD staging(P<0.05).1.2 The distribution of empirical symptom:The syndrome of wet turbid is the most common,the rest are water and gas syndrome,blood stasis syndrome,damp heat syndrome and wind movement syndrome.There was no statistical difference between the empirical symptom and gender,age and CKD staging(P>0.05).1.3 The deficiency syndrome and empirical symptom distribution:Spleen and kidney yang deficiency with wet turbid syndrome is the most,the syndrome of liver kidney yin deficiency with damp heat syndrome is the most,the deficiency of spleen and kidney qi with wet turbid syndrome and water and gas syndrome is the most,Qi Yin two deficiency syndrome and water and gas syndrome is the most,yin and yang two deficiency syndrome and damp heat syndrome is the most.The highest frequency distribution is spleen and kidney yang deficiency and wet turbid syndrome.2.Relationship between TCM syndrome types and Laboratory indicators2.1 The relationship between the deficiency syndrome and Laboratory indicators:There was a significant difference between the deficiency syndrome and CO2 CP and PTH(P<0.05),but there was no significant difference between SCR,BUN,UA,Hb,Ca and P(P>0.05).2.2 The relationship between empirical symptom and Laboratory indicators:There was a significant difference between the empirical symptom and Hb(P<0.05),but there was no significant difference between SCR,BUN,UA,CO2 CP,PTH,Ca and P(P>0.05).Conclusion:1.In stage CKD3-5 with SHPT,the spleen kidney yang deficiency syndrome is the most common deficiency in the deficiency syndrome.The most common empirical symptom is wet turbid syndrome.The spleen and kidney yang deficiency syndrome and wet turbid syndrome are the most in the deficiency syndrome and empirical symptom.The syndrome type of TCM of CKD3-5 patients with SHPT was not related to sex and age.There is no relation between the empirical symptom and the CKD staging.The deficiency syndrome is closely related to the CKD staging,and the incidence of the disease increases with the increase of CKD staging.2.The deficiency syndrome in the CKD3-5 phase with SHPT is closely related to CO2 CP and PTH,and there is a correlation between empirical symptom and Hb.