Expression And Clinical Characteristics Of MicRNA-214 In Patients With Coronary Artery Disease

Objective:To detective the expression and characteristics of plasma microRNA-214(miR-214)in patients with coronary artery disease(CAD)and find the relationship between MiR-214 and onset time,level of stenosis and scores of Gensini.Provide the basis for miR-214 become a new CAD diagnaostic biomarker and drug taget.Method:Thirteen cases of acute myocardial infarction(AMI)patients and 27 cases of healthy volunteers were compared;22 cases of CAD patients with chest pain and 8 cases of non CAD patients with chest pain were compared;154 patients with complex coronary artery lesions in patients with acute chest pain and 92 patients without coronary artery stenosis in patients with acute chest pain were compared.All case's miR-214 expression and concertation of cardiac troponin-I(cTnI)were measured.Analyze the miR-214's relationship with the time of AMI onset time,the degree of coronary artery stenosis,and Gensini score of CAD patients.Results:miR-214 was enriched in the plasma of CAD patients.Compared with the healthy control,the miR-214 in AMI patients significantly increased after AMI onset(P<0.05),the plasma miR-214 level in AMI paitents was positively correlated with cTnI concentration(r=0.596,p<0.05);The level of plasma miR-214 was positively correlated with degree of coronary artery stenosis in CAD patients(r=0.554,p<0.05);miR-214 level and CAD Gensini score was positively related(r=0.480,p<0.001).Conclusion:Circulating miR-214 may be a new biomarker for CAD and as a potential diagnostic tool.And increased miR-214 level may be used to predict the presence and severity of coronary lesions in CAD patients.