| Research background: Limb fractures are one of the most common types of clinical fractures.In recent years,with the increase of traffic accidents and the development of competitive sports,the incidence of limb fractures has increased year by year.Limb fractures are mostly open fractures caused by high energy damage,and the fracture ends are in direct contact with the external environment,which is easy to be contaminated.In addition,the damage to the soft tissues and vascular nerves at the fracture sites with different degrees also weaken the ability of surrounding tissues to heal and resist pathogenic bacteria.Thus,the postoperative infection rate of patients with fractures remains high.For some complicated and serious fractures,even timely treatment cannot completely prevent the occurrence of infection.Although more advanced treatments have been used in recent years,the hospital infection rates after limb fractures remain high.Postoperative infection not only causes delayed wound healing,affects fracture recovery,and leads to osteomyelitis,but also increases the risk of amputation and the cost of treatments.Therefore,it has become an extremely important research hotspot in the field of orthopedics to find easy-to-use detection data to evaluate the risk of postoperative infection and seek early prevention and treatment of infection.Detection of T lymphocyte subsets is mainly used to understand whether the body's immune function is balanced.The high or low proportion of a certain subgroup indicates the disorder of immune function and the risk of tumor,infection and autoimmune diseases.Some studies have shown that certain inflammatory factors are the initiating and maintenance factors that cause inflammation and play an important role in the whole process of infection and development.The inflammatory factors will change significantly when the infection occurs.Therefore,the purpose of this paper is to comprehensively analyze the relationship between these two indicators and postoperative hospital infection of limb fractures through the combined detection of T lymphocyte subsets and inflammatory factors,to provide a theoretical basis for the clinical prevention and treatment of postoperative infection in patients with limb fractures.Purpose: to investigate the correlation of T lymphocyte subgroup associated inflammatory factor detection with postoperative hospital infection of extremities fracture.Methods: to choose between August 2014 and August 2017 hospital patients,620 cases of extremities fractures treated by surgery,according to whether the postoperative infection were divided into infection and the infection group,cells to take the method of joint detection of patients admitted to hospital and postoperative serum levels of T lymphocyte subsets of 24 h and the level of inflammatory factors,Logistic regression analysis method are used to observe its relevance to patients with postoperative infection.Results: when the group of patients admitted to hospital infection and postoperative 24 h percentage of CD4 + cells and CD4 + / CD8 + ratio,percentage of Th1 cells and Th1 / Th2 ratios were significantly lower than uninfected group,the percentage of CD8 + cells and Th2 cells percentage is significantly higher than the infection group,difference has statistical significance(P < 0.05),a group of patients admitted to hospital infection and postoperative 24 h when IL-6,IL-8 and TNF alpha level were higher than in patients without infection group,the multi-factor Logistic regression analysis results show that the percentage of CD4 + cells and CD4 + / CD8 + ratio,percentage of Th1 cells and Th1 / Th2 ratio,IL-6,IL-8,TNF alpha is relevant factors of hospital infection postoperatively in patients with limbs fracture(P < 0.05).Conclusion: the early admission joint detection of T lymphocyte subgroup and inflammatory factor,which can effectively evaluate patients postoperative infection risk,and then take corresponding preventive measures to reduce the infection rate,worthy of clinical popularization and application. |
PDF Full Text Request