| Objective: To explore the clinic effect of immune enhancer--pyrazoleketones mott(pidotimod particles),which used in treatment of chronic sinusitisof children, and observe the activity level changes in the peripheral blood Tlymphocyte subsets and NK cells, and evaluate the immune regulator effectson the immune function of chronic sinusitis in children.Methods: Collected7~14years old120school-aged children who werediagnosed of chronic sinusitis from March2012to June2013in the hospitalof North-Sichuan medical college. The subjects were diagnosed based onsubjective symptoms, according to the visual analog scale (VAS) scoremethod, and were divided into3groups--light, moderate and severe,40casesin each group.Then the children in3groups were divided randomly intoexperimental group (group B) and control group (group A), which20cases ineach group. the experimental group and control group have a total of60cases:control group were given antibiotics, saline flushing the nose andfluticasone propionate nasal spray nasal spray in1month. Simultaneously, theexperimental group in group A had moder grains besides of the program ofcontrol group (by oral, in1month. Respectively to compare the total scorechanges of preparation before and after1month and were followed up for6months, with VAS and Lund-Kennedy,.Collected the peripheral bloodsamples after medicated in24~48h, before and after1months, and6months after discontinuation.Through using flow cytometry (FCM), we were detected in blood samples three times the percentage of CD3+, CD4+, CD8+,CD4+/CD8+ratio and NK cell activity level.Results: According to data:(1) By comparing1months and6monthsfollow-up after treatment, control group and experimental group were alllower about VAS score and Lund-Kennedy scores than before treatment; theexperimental group score more obvious reduction,which displayed that twogroups of children with symptoms and endoscopic signs were improved aftertreatment,while group B (experiment) improve more obvious; the differencebetween two groups was statistically significant (P<0.05);(2) Six monthsafter stopping drug, the curative effect of experimental group and controlgroup has the recurrence rate in terms of efficiency. The experimental group(80%) is significantly higher than control group (60%)(P<0.01).In terms oftotal effective rate, the experimental group (96.7%) is significantly higherthan control group (60%)(P<0.01). According to the recurrence rate, theexperimental group (6.7%) was significantly lower than the control group(20.0%)(P<0.05), while the therapeutic effect of the experimental group withsignificantly higher than the control group;(3)All children in the process oftreatment have no obvious adverse reactions;(4) The peripheral blood, whichof children in experimental group in1month and6months after treatment,with the percentage of CD3+, CD4+, CD8+, CD4+/CD8+ratio, which havedifference compared to before treatment and control group with statisticalsignificance (P<0.01). So, that the result is, peripheral blood CD3+, CD4+,CD4+/CD8+ratio and the percentage of NK cell activity were significantlyincreased, and the peripheral blood CD8+percentage more than beforetreatment and the control group significantly reduced.Conclusion:(1) Immune regulator of new pattern pidotimod can improve the efficacy of chronic sinusitis in children, and it is a securitytreatment.(2) The immune enhancer (pyrazole ketones mott) make the cellularimmune function in a rising state after intervention in1months.Even afterstopping drug in6months, the immune function imbalance continue toreverse. This study illustrate that the immune modulators can improve the patient’s immune function obtained the certain effect. |
PDF Full Text Request