Retrospective Analysis Of Metabolic Abnormalities In Patients With Polycystic Ovary Syndrome And Their Parents

BACKGROUND:Polycystic ovary syndrome(PCOS)is a common female reproductive endocrine disorder with endocrine and metabolic abnormalities such as oligo-ovulation and/or anovulation,polycystic changes in the ovary,and clinical and/or biochemical hyperandrogenism.PCOS clinical phenotype is complicated and heterogeneous obviously.The prevalence of PCOS in women of reproductive age is about 6%-10%.It has a tremendous adverse impact on metabolism of the body as it develops.Previous studies have shown that family genetic factors may play a part in the clinical manifestations of PCOS patients,The metabolic status of PCOS patients may be related to their parents' metabolism.OBJECTIVE:To investigate the relationship of metabolic abnormalities in patients with PCOS and their parents.METHODS:A total of 201 PCOS trios families with 603 individulas were enrolled from the clinics of Center for Reproductive Medicine,Shandong University from June 2014 to April 2017,according to the 2011 Chinese diagnostic criteria.Firstly,we collected the clinical characteristics such as height,weight,BMI,waist circumference,hip circumference,waist-to-hip ratio,blood pressure,menstruation history,childbearing history,pharmacohistory,previous history,etc.in the form of a questionnaire.Secondly,auxiliary examinations:B-ultrasound to measure the size of the ovary and the number of the follicles;blood tests of FSH,LH,E2,PRL,T,P,TSH,,fasting glucose and insulin,blood lipids etc.Thirdly,collectiing parents information of the age,height,weight,waist circumference,hip circumference,hairy score,menstrual history,disease history;we also measured the blood blood pressure,blood lipids,fasting glucose and insulin.4.Grouping:,one and/or both parents had abnormal results were taken as abnormal groups;otherwise were as control normal parents groups.Abnormal grouping criteria:fasting blood glucose(FBG)greater than 6.1 mmol/L;total cholesterol(CHO)is greater than 6.2 mmol/L,triglyceride(TG)is greater than 2.3 mmol/L,low-density lipoprotein cholesterol(LDL-C)greater than 4.1 mmol/L,high-density lipoprotein cholesterol(HDL-C)less than 1.07 mmol/L,satisfying any of them can be considered as dyslipidemia;BMI>24 is overweight or obesity.5.The association between the clinical characteristics of PCOS between abnormal patients group and corresponding control group were analysed by Spearman correlation.Results:Among the PCOS patients,the number of parents with abnormal BMI was 153,the number of normal families was 28,and the abnormal rate was 84.5%.The number of families with abnormal blood glucose was 93,and the number of normal families was 55.The abnormal rate was 62.8.%;the number of families with dyslipidemia was 80,and the number of families with normal blood lipids was 29,and the abnormal rate was 73.3%;Compared with the group of normal BMI parents,the BMI of the progeny PCOS patients in the group of parents with abnormal BMI was significantly higher(P<0.0001);Compared with the group of parents with normal blood glucose,the FBG of the progeny PCOS patients was significantly increased(P<0.05)in the group of parents with abnormal FBG;Compared with the group of parents with normal blood lipid,CHO(P<0.05),LDL-C(P<0.05),HDL-C(P<0.05),TG(P<0.0001)are significantly different in the parental dyslipidemia group.Conclusion:The incidence of metabolic dysfunctions in parents of PCOS is high;offspring PCOS patients are significantly associated with their parents' abnormalities in BMI,blood glucose and lipid.The metabolic abnormalities of parents may be an inducement for metabolic disorders in patients with PCOS.