The Association Of Obstructive Sleep Apnea-hypopnea Syndrome And Coronary Artery Calcification Score

Purpose:Obstructive sleep apnea hypopnea syndrome?OSAHS?is a clinically common sleep disorder.This study focused on the association of obstructive sleep apnea hypopnea syndrome and the patients'coronary artery calcification score who was with coronary heart disease?CHD?but don't have syndrome.With the aim of providing basis for early diagnosis and treatment of patients with coronary heart disease complicated with OSAHS.Information and Methods:Selecting patients with OSAHS or delirium complicated with coronary heart disease who visited our hospital from July 2014 to February 2017 due to repeated snoring,apnea,nighttime dry mouth,inattention,and lethargy.The patients with PSG and coronary CTA examination were included,with previous coronary stent implantation or thrombolytic therapy and coronary heart disease symptoms such as typical coronary heart disease,typical chest tightness,chest pain,and with severe respiratory disease,kidney disease were excluded.A total of 73people were included in the study.Collecting patients'polysomnography respiratory monitoring data,coronary artery calcification scores,height,weight,blood pressure,blood glucose and lipids from the case date,and body mass index?BMI?was calculated.According to the apnea hypopnea index?AHI?,patients were divided into mild to moderate OSAHS group?AHI?30/h?and severe OSAHS group?AHI>30/h?,Comparing sleep-related parameters,coronary artery calcification scores,prevalence of hypertension,cholesterol,fasting blood glucose,and other differences among groups.The coronary calcification score?50%was classified as"group A",and the coronary calcification score was>50%classified as"group B".The differences in sleep-related parameters,prevalence of hypertension,smoking prevalence,cholesterol,and fasting blood glucose were compared between"A and B"groups.Spearman correlation analysis was used to investigate the correlation between coronary artery calcification scores and sleep-related parameters,cholesterol,and fasting blood glucose.Multiple linear stepwise regression analysis was used to investigate the independent risk factors of OSAHS related parameters and coronary artery calcification scores.Results:1.According to AHI,OSAHS patients were divided into mild-to-moderate OSAHS group and severe OSAHS group.There was no significant difference in age,hypertension,cholesterol,triglyceride,blood glucose and BMI between mild-to-moderate OSAHS group and severe OSAHS?P>0.05?.The proportion of males?88%?in the severe OSAHS group was larger than the mild-to-moderate OSAHS group?67%?,and the difference was statistically significant?p=0.03?.There were significant differences in AHI,LaSO₂,TS90%,and coronary artery calcification scores between mild-to-moderate OSAHS group and severe OSAHS group?P=0.00,0.00,0.00,0.00?.The severe OSAHS group had higher AHI,TS90%,coronary calcification scores,and lower LaSO₂ than the mild-to-moderate OSAHS group.The smoking rate in severe OSAHS group?79%?was higher than mild-to-moderate OSAHS group?33%?,and the difference was statistically significant?P=0.00?.2.The female group was older than the male group and the difference was statistically significant?P=0.00?.The smoking rate was higher in the male group than in the female group,with a statistically significant difference?P=0.00?.There was no significant difference in the prevalence of hypertension,BMI,cholesterol,triglyceride,fasting blood glucose,TS90%,AHI,LaSO₂,coronary artery calcification in the two groups?P=0.726,0.239,0.873,0.165,0.872,0.441,0.083,0.083,0.129?.3.Spearman correlation analysis showed that coronary artery calcification score was positively correlated with AHI and TS90%?r=0.562,0.397;P=0.00,0.00?,and negatively correlated with LaSO₂?r=-0.556;P=0.01?.In the male group,the coronary artery calcification score was positively correlated with BMI,AHI,and TS90%?r=0.37,0.620,0.544;P=0.005,0.00,0.001,?and negatively correlated with LaSO₂?r=-0.433;P=0.001?.In the female group,no coronary artery calcification scores were associated with OSAHS parameters.4.Patients with a coronary calcification score?50%were classified as"group A",and those with a coronary calcification score>50%were classified as"group B".There was a statistically significant difference in AHI,LaSO₂,and TS90%between“group A”and“group B”?P=0.00,0.00,and 0.00?.“group A”had higher LaSO₂ than“group B”,and“group B”had higher AHI and TS90%than“group A”.There was no significant difference in gender,age,prevalence of hypertension,smoking rate,BMI,cholesterol,triglyceride,and fasting glucose between“group A”and“group B”?P=0.187,0.468,0.258,0.124,0.868,0.849,0.377,0.60?.5.Using multivariate linear stepwise regression analysis with coronary artery calcification as the dependent variable,logAHI,logLaSO₂,and logTS90%were included as independent variables in the regression analysis.The results showed that logAHI and logTS90%may be the main predictors of coronary artery calcification scores??=0.327,0.299;P=0.011,0.020?.Conclusions:In OSAHS patients,AHI,LaSO₂,and TS90%were associated with coronary calcification scores,and logAHI and logTS90%may be the main predictors of coronary artery calcification scores.