| Purpose:By observing Danzhi Xiaoyao San and Xiaochaihu Tang addition and subtraction combined with methimazole treatment of patients with Graves hyperthyroidism(liver-fire exuberance syndrome),compared with simple methimazole treatment of Graves hyperthyroidism patients were observed differences in efficacy between the two groups,to explore the method of releasing stagnation and dissolving vexationn,inhibiting yang and strengthening yin for the clinical diagnosis and treatment of hyperthyroidism clinical value.Methods:Thirty-seven patients with Graves Hyperthyroidism(liver-fire exuberance syndrome)met the inclusion criteria who were selected and randomly divided into control group(36 cases)and treatment group(36 cases).The control group,depending on the severity,given appropriate amount methimazole as the initial dose,can be single or 3 times / day.When the clinical symptoms were significantly improved,the level of thyroid hormone gradually reduced gradually after surgery,about every 2 to 4 weeks to reduce the drug,each reduction of 5 ~ 10 mg,until the minimum maintenance dose of about 5 ~ 10 mg / d.On the basis of the control group,the treatment group was treated with Danzhi Xiaoyao San and Xiaochaihu Tang addition and subtraction,1 dose / day,3 times / day,after meals.Two groups of patients were 4 weeks for a course of treatment,taking 3 courses.Before and after treatment,the symptoms and signs of TCM,TCM syndrome scores,relevant laboratory parameters(including TSH,FT3,FT4,blood routine,liver and kidney function,stool and urine routinee,ECG and so on)were observed before and after treatment.And record the adverse reactions in the course of treatment.The data using SPSS24.0 software for statistical and analysis.Results:1.Clinical curative effect: After treatment,treatment group of patients with clinical control in 10 cases,accounting for 27.78%;18 cases markedly effective,accounting for 50%;effective in 8 cases,accounting for 22.22%;invalid patients in 0 case,.The control group of patients with clinical control in 6 cases,accounting for 16.67%;markedly effective in 12 cases,accounting for 33.33%;effective in 17 cases,accounting for 47.22%;invalid patients in 1 case,accounting for 2.78%.The difference was statistically significant(P<0.05).2.Thyroid function(TSH,FT4,FT3): After the end of treatment,the difference between the two groups was statistically significant(P<0.01).At different times of thyroid function between the two groups: After 4 weeks of treatment,there was significantly different in TSH,FT4 and FT3 between the two groups(P<0.05).After 8 weeks of treatment,there was no significant difference in TSH between the two groups(P>0.05),FT4 was significantly different(P<0.05),FT3 value was no significant difference(P>0.05).After 12 weeks of treatment,there was no significant difference in TSH,FT4 and FT3 between the two groups(P>0.05).3.TCM Syndrome Points: After treatment,the scores of TCM syndromes before treatment in both groups were significantly different(P<0.01).The scores of TCM syndromes between the two groups after treatment were statistically significant(P<0.05).4.Symptoms and signs: After treatment,two groups of irritability,less sleep soundly,mouth pain and goiter symptoms,the difference was statistically significant(P<0.05);after treatment,two groups of heart palpitations restless,resting pulse rate,polyphagia,thin,hyperhidrosis,hand and tongue tremor,fear of heat,eyestrognosis,the difference was not statistically significant(P>0.05).5.Safety analysis: During the course of treatment,leukopenia was observed in one patient in the treatment group,leukopenia was observed in two patients in the control group,and mild liver function impairment occurred in one patient.The incidence of adverse reactions in the treatment group was lower than that in the control group.There is no abnormalities during the treatment of patients with vital signs,kidney function,stool and urine routinee,ECG.Conclusions:1.Chinese medicine Danzhi Xiaoyao San and Xiao Chai Hu Tang addition and subtraction combined with methimazole,compared with the simple use of methimazole,can improve the Graves hyperthyroidism(liver-fire exuberance syndrome)in patients with clinical efficacy.2.Both treatment group and control group could promote the recovery of thyroid function in patients with Graves hyperthyroidism.Compared with the control group,simply using methimazole,Chinese medicine Danzhi Xiaoyao San and Xiaochaihu Tang addition and subtraction combined with methimazole for the recovery of methylation more rapidly.3.The treatment group and the control group can improve the clinical symptoms and signs of patients with Graves hyperthyroidism(liver-fire exuberance syndrome).Compared with the control group simply using methimazole,Chinese medicine Danzhi Xiaoyao San and Xiaochaihu Tang addition and subtraction combined with methimazole can better reduce the patients’ TCM syndrome scores,and can significantly alleviate the patient’s irritability,less sleep soundly,mouth pain and goiter symptoms.4.Danzhi Xiaoyao San and Xiaochaihu Tang addition and subtraction combined with methimazole for hyperthyroidism(liver-fire exuberance syndrome)patients compared with the simple use of methimazole can reduce the incidence of adverse reactions.5.The treatment of hyperthyroidism(liver-fire exuberance syndrome))by inhibiting yang and strengthening yin has a certain clinical application value. |
