| Objective: Retrospective case analysis was conducted to investigate the incidence of erectile dysfunction(ED)comorbidity in depressed patients,and to investigate relationships of the severity of depressive symptoms,age and ED,and other influencing factors of the depression severity.Methods: The International Erectile Function National Questionnaire(IIEF-5)assesses the degree of erectile dysfunction,the degree of depressive symptoms were assessed by the Hamilton Depression Rating Scale(HAMD-17)score.The incidence of ED in depressed patients,IIEF-5 scores of different degrees of depression in patients comorbid ED and IIEF-5 scores of ED comorbid patients with depression in different age groups were used to analyze the relationship between the severity of depressive symptoms,age and ED.Results: 1.The survey and analysis showed that the incidence of ED in patients with depression increased with deteriorating symptoms.The incidence of ED in patients with mild,moderate,and severe depression was 11.1%,20.5%,and 77.8%,respectively.2.The IIEF-5 erectile scores of mild,moderate and severe depressed patients who comorbid ED were 19.33±1.15,18.44±3.09,and 12.57±5.14.Kruskal-Wallis H test and Bonferroni correction showed that the IIEF-5 erectile score of severe depression comorbid ED patients was significantly lower than moderate ones(P<0.05),means that the erectile function of the former was obviously decreased when comparing the later.Meanwhile,there was no significant difference between severe depression and mild depression or moderate depression and mild depression.3.With the increase of age,the prevalence of ED comorbid depressive disorders also increased.The incidence of ED in depressed patients age 26-35(including 35),36-45(including 45)and 46-55(including 55)were 17.1%,27.3%,and 52.4%,respectively.4.The IIEF scores of the abovementioned three age groups were 14.83±4.71,16.89±5.42,and 14.45±5.35,respectively.Fisher's Least Significant Difference Test and multiple comparisons showed that the erectile scores of each age group did not significantly differ from other age groups(P>0.05).5.Univariate logistic regression analysis showed that HAMD scores(OR=1.25,95%CI:1.12~1.38),depression severity and age(OR=1.13,95%CI:1.04~1.22)were remarkably associated with the comorbidity of ED(P<0.05).The risk of ED tended to be higher,having higher value of HAMD,greater severity of depression and older age.Concomitantly,depressed patients age 46-55 were more likely to comorbid ED than were patients age 26-35(P<0.05)rather than age 36-45(P>0.05).6.Multivariate logistic regression analysis showed that the decrease of erectile function as well as comorbid ED were risk factors of severe depression(P<0.05).Age had significant effects on mild depression and moderate depression(P<0.05).The older the age,the greater the possibility of moderate depression than mild depression.In addition,patients age 26-35 had an increased risk of severe depression rather than moderate depression when comparing with other age groups.Conclusion: The increase of depression severity and age were risk factors of depressive disorders comorbid ED.Age did not have remarkable effect on the erectile function of depressive patients.The decrease of erectile function as well as comorbid ED were risk factors of severe depression.Age had significant effects on mild depression and moderate depression.Depressed patients age 26-35 had an higher incidence of severe depression rather than moderate depression.In daily clinical practice,psychiatrists should pay due attention to erectile function of male depressed patients,especially young men with severe depression.Careful inquisition,comorbidity mining,well-considered selection of antidepressants which reducing the effects on sexual function,all these efforts should be made to maximize the recovery of both sexual function and social function,for further improvement of patients' quality of life. |
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