Analysis Of Related Factors For Gleason Score Upgrade After Radical Prostatectomy

Objective By analyzing the factors that lead to lower Gleason score of preoperative excision of prostate cancer compared with Gleason score after radical resection,a better diagnosis and treatment plan is provided for patients.Methods We retrospectively analyzed 91 patients who underwent prostate biopsy and radical prostatectomy both in our hospital From October 2016 to March 2018.The interval between needle biopsy and radical prostatectomy in selected patients was less than 3months.According to whether the Gleason score of prostate cancer after radical prostatectomy was the same as the Gleason score before radical prostatectomy,the patients were divided into the identical group and the elevated group.Patients with higher Gleason score after preoperative puncture than after radical prostatectomy will not be included in the case study.We compared the two groups of patients in the aspect of age,PSA,prostate volume,BMI,puncture needle number,puncture method,puncture Gleason score and so on to finger out whether there was statistically significant difference,and then the influencing factors of the lower Gleason score before radical resection compared with Gleason score after radical resection were obtained.Results By analyzing the potential factors that lead to lower Gleason score of preoperative excision of prostate cancer compared with Gleason score after radical resection,these clinical factors include age,body mass index(BMI),PSA level before needle biopsy,and puncture method(both methods puncture needles ≥ 12 needles)were found not to be related with the escalation of pathological scores after radical surgery;smaller prostate volume(P=0.043)and low pathological score before radical surgery(P=0.031)were found to be all independent predictors for upgrade.Conclusion Findings of this study revealed that in patients with preoperative GS≤6,smaller prostate volume were associated with the upgrade of GS.Therefore,it should be considered when selecting treatment modalities among these patients.