Analysis Of Risk Factors Of 150 Patients With Colorectal Cancer

Objective:To analyze the clinical characteristics of 150 patients with colorectal cancer through retrospective analysis,analyze and summarize the risk factors that cause colorectal cancer,and provide theoretical basis for better clinical prevention and treatment of colorectal cancer.METHODS:The clinical data of 150 patients with colorectal cancer in the second hospital of Tianjin Medical University from 2012 to 2017 and 300 patients in the same period were analyzed retrospectively.SPSS19.0 data system was used for data analysis.Descriptive analysis was used for general features.Two independent samples t-tests were used for comparison between the two groups.Count data were analyzed using?2 test,and one-way ordered data were ranked using Mann-Whitney.U test method,and multivariate logistic regression analysis.P<0.05 was considered statistically significant.RESULTS:1.In 150 cases of colorectal cancer,there were 50 cases of rectal cancer(33.3%)and25 cases of sigmoid colon cancer(16.7%).The most common pathological type was adenocarcinoma(139 cases,92.7%).2.The average age of patients with colorectal cancer was(64.11±13.30)years.The cumulative number of patients under the age of 50 was 11 cases(7.3%),and 139cases(92.7%)were over the age of 50.The incidence peak was between 60 and 70years old.45 cases,accounting for 30%.3.Univariate analysis:smoking(χ~2=18.000,P=0.000,OR=2.406),inflammatory bowel disease(χ~2=11.928,P=0.001,OR=9.511),colorectal polyps(χ~2=41.791,P=0.000,OR=6.931),gallbladder disease and cholecystectomy(χ~2=12.104,P=0.001,OR=2.958),type 2 diabetes(χ~2=3.944,P=0.047,OR=1.638),first-degree relatives with colorectal cancer Positive family history(χ~2=20.455,P=0.000,OR=1.071),hyperlipidemia(χ~2=4.492,P=0.034,OR=1.677),history of malignancy of non-colorectal cancer(χ~2=6.363,P=0.019,OR=6.208),the use of aspirin(χ~2=4.930,P=0.026,OR=0.506)associated with the incidence of colorectal cancer.Gender,drinking,appendectomy,Helicobacter pylori infection,obesity were not associated with the incidence of colorectal cancer(P>0.05).4.Total cholesterol in the case group(5.61±0.65)was significantly higher than that in the control group(4.82±0.54)(t=2.40,P=0.023);the High density lipoprotein-cholesterol in the case group(0.85±0.26)was lower than that of the control group.There was statistical difference in High density lipoprotein-cholesterol(1.27±0.27)(t=–3.56,P=0.002)between the two groups;Low density lipoprotein-cholesterol LDL-C and Triglyceride in the two groups were not statistically different by t test.5.Multivariate Logistics results:smoking OR=2.475,colorectal polyps OR=6.499,gallbladder disease and cholecystectomy OR=3.584,positive family history of first-degree relatives with colorectal cancer OR=14.736,history of malignant tumors of colorectal cancer OR=5.620,the above factors are independent risk factors for the onset of colorectal cancer.Conclusions:1.The incidence of colorectal cancer is mainly middle-aged and old.2.Smoking,inflammatory bowel disease,colorectal polyps,gallbladder disease and cholecystectomy,type 2 diabetes,positive family history of first-degree relatives with colorectal cancer,history of hyperlipidemia and non-colorectal cancer,the use of aspirin Associated with the incidence of colorectal cancer.3.Smoking,colorectal polyps,gallbladder disease and cholecystectomy,positive family history of first-degree relatives with colorectal cancer,and history of non-colorectal cancer were independent risk factors for colorectal cancer.