| Genitourinary Chlamydia trachomatis infection has become the most prevalent sexually transmitted disease in the world.An investigation shown that the infection rate of men and women who have active sex lives had been higher than 5%.And this trend has not been effectively curbed,but intensified.The treatment of this disease is mainly based on oral antibiotics.While Ct has shown resistance to various antibiotics in varying degrees,and during the treatment period,more and more patients had reinfection or persistent infection.Chlamydia trachomatis(Ct)is very harmful to human body.Genital Chlamydia trachomatis infection can cause epididymitis,urethritis,prostatitis,premature ejaculation,cervicitis,pelvic inflammation,salpingitis,abortion,infertility and many other severe secondary diseases,which seriously has damaged the physical and mental health of patients and patients' confidence in treatment.How to effectively prevent and treat Chlamydia trachomatis infection in urogenital tract has been an urgent problem.Vitamin D is a necessary nutrient for the human body.It plays a key role in calcium-phosphorus metabolism.As more and more studies shown that vitamin D also played an important role in the human immune system and is closely related to many infectious diseases,such as leprosy,tuberculosis,rotavirus infection,chronic hepatitis B and influenza,Vitamin D has got a new important identity.As Ct infection is an infectious disease and its pathogenesis closely related to human immunoreaction,we have a great interest in the correlation between vitamin D and Ct infection.The purpose of this study is to explore the correlation between vitamin D level and the risk of genital Ct infection and therapeutic effect of this disease,and to provide a possible direction for the prevention and treatment.Objective: To investigate the correlation between serum vitamin D levels in human body and genital Chlamydia trachomatis infectionMethods: From 11,1,2016 to3.15,2017,we recruited 174 outpatients(male 95,female 79,age 20 to 49)infected with Chlamydia trachomatis and 380 healthy volunteers(male 211,female 169,age 20 to 49)in Tianjin.We took blood of volunteers for once while patients for twice,in the morning before and after thecourse of antibiotic treatment,on an empty stomach.The serum 25-(OH)D levels was measured with enzyme-linked immunoassay(ELISA)method.One month after a course of treatment,the PCR assay was used to assess the cure of this disease.Then we randomly selected samples from the collected and two case-control studies was conducted.We got respectively 161 infected cases with Ct and 161 healthy control subjects,41 uncured cases with and 41 cured control subjects,both of whose frequency were matched by gender and age.Statistical analysis was performed by SPSS19.0,and the difference was statistically significant if P < 0.05.Results: The two case-control studies showed that lower serum vitamin D level was a risk factor of both genital chlamydial infection and the poor result of treatment,of which the adjusted ORs were 2.281(95% CI:1.438,3.619)and7.266(95% CI:2.551,21.036).In the 20-39 age group of all samples collected The25-(OH)D level in male patients,(40.10 ± 17.93)nmol/L,was lower than(53.72 ±18.00)nmol/L in healthy man,and the 25-(OH)D level of female patients,(35.71±19.99)nmol/L,was lower than(45.42±16.08)nmol/L in healthy women.Both of the differences were statistically significant(P < 0.01);The 25-(OH)D level of uncured male patients,(30.50±14.53)nmol/L,was lower than(41.32±17.24)nmol/L in cured male patients and the 25-(OH)D level of uncured female patients,(29.47 ±16.66)nmol/L,was lower than(41.37±21.03)nmol/L in cured female patients.Both of the difference was statistically significant(P < 0.05).Conclusions: the serum vitamin D levels in human are related to genitourinary Chlamydia trachomatis infection and the effect of the treatment.Lower serum vitamin D level may increase the genitourinary chlamydial infection rate,and reduce the effect of treatment. |
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