Study The Relationship Of Serum Uric Acid Level With Alzheimer's Disease

BackgroundIt has been suggested that oxidative stress have a role in the pathogenesis of Alzheimer's disease(AD).Uric acid is a water-soluble antioxidant that is endogenously produced.Low levels of uric acid may impair the antioxidant capacity of nerve cells.Therefore,increasing serum uric acid levels may reduce the risk of AD and delay the progression of the disease.However,high levels of uric acid are not only the main pathogenic factors of gout,but also are important factors in promoting the occurrence and progression of cardiovascular diseases.Cardiovascular disease and cardiovascular risk factors were significantly associated with increased risk of AD and dementia.Therefore,there is a contradiction in the relationship between uric acid and AD.Whether high uric acid level is a protective factor or a risk factor for AD,there was still lack of clear conclusion.ObjectiveTo assess the relationship between serum uric acid level and cognitive function in AD patients.MethodsSerum uric acid levels were measured and other relevant biochemical indicators were recorded in 146 patients with AD and 89 normal controls.All participants performed systematic cognitive function assessments and analyzed the effects of serum uric acid levels on cognitive function.ResultsSerum uric acid levels in AD group were not significantly different from that in the normal control group,but the proportion of low uric acid levels(<240 ?mol/L)and high uric acid levels(>480 ?mol/L)increased in the AD patients,especially in the male population(P= 0.028).Logistic regression analysis showed that high levels of uric acid may increase the risk of AD in males(OR = 2.74,95% CI 1.02-7.40)after adjusting for confounding factors such as age and education level.Linear regression analysis showed that after adjusting for confounding factors such as age,gender,education level and serum creatinine levels,serum uric acid levels in AD patients were negatively correlated with activities of daily living,but there was no significant correlation with cognitive domains such as global cognitive function,memory,language,visual space,and executive function.ConclusionsHyperuricemia levels may increase the risk of AD in the male population.Serum uric acid levels may not be associated with cognitive impairment in AD patients.