Impairment Of Prefrontal Amygdala Functional Connectivity In Female Patients With Bipolar Disorder At Different Ages

Objective:For a single gender female,with 25 years as the age line,select the amygdala region of interest,the application of brain function in resting state magnetic resonance,study of 13~25 women,and 26~45 year old age patients with bipolar disorder prefrontal amygdala neural circuits compared to healthy people with no abnormal functional connectivity,in order to find out the factors on age patients with bipolar disorder of brain function,to explore the neurobiological basis of bipolar disorder in women of different ages.Methods:The FMRI date were acquired from 30 patients with bipolar disorder aged from 13-25,and 30 age –and level of education –and gender matched health controls;30 patients with bipolar disorder aged from 26-45,and 30 age –and level of education –and gender matched health controls to find the patients and health controls frontal lobe-amygdala functional connections,the date was calculate by MATLAB –based DPARSF software.Results:Compared with HC aged from 13-25 patients the lobe-amygdala functional connections significantly decreased.Compared with HC the aged from 26-45 patients has no significantly difference.Conclusion:The frontal lobe-amygdala functional connections decreased in aged from 13-25 female patients may related to the brain underdeveloped and vulnerable,The aged from 26-45 female patients has no significantly difference may suggest the patients in this age paragraph has no damaged in frontal lobe-amygdala functional connections.