Correlation Between Growth Rate And Pathological Types Of Uterine Smooth Muscle Tumors

Objective: A retrospective study on the clinical and pathological types of uterine smooth muscle tumors,uterine smooth muscle tumors mainly for clinical diagnosis and referral by ultrasonic,ultrasound can show the size of uterine leiomyoma and blood supply.Accurate three-dimensional measurement and quantitative analysis of blood vessels.Monitoring of growth rate and blood flow distribution by 2D and 3D PDI,correlation between growth rate and vascularisation index(VI),compared with postoperative pathological type correlation analysis of growth rate and VI and different tumor types.The diagnosis and differential diagnosis of benign and malignant leiomyoma and malignant potential of the indeterminate smooth muscle tumors and the growth of active leiomyoma are mainly based on the pathological manifestations of histology,including tumor cells is more than moderate,and whether the count of nuclear fission is more than 10/10 HPF,Whether there are coagulation necrosis(or tumor cell necrosis)of the three main factor.Because of the variety of the pathological changes,such as nuclear pyknosis,nuclear fragmentation,apoptotic cells and necrotic cells,the accuracy of the nuclear fission image is accurately counted.This study compared the three methods of H&E-MI,Ki-67 and PHH3 in the diagnosis of uterine smooth muscle tumors.To analyze the correlation,distribution and specificity of uterine smooth muscle tumor growth rate,VI and PHH3,Ki-67 and H&E-MI in different types of smooth muscle tumors.Try to predict the benign and malignant tumors by tumor growth rate and VI,and provide a new reference for the clinical diagnosis of uterine smooth muscle tumors.Methods: Of the 180 patients with uterine smooth muscle tumors confirmed: 21 LMSs,23STUMPs,21 BLMs,27MALs and 88 LMs for ultrasound monitoring and pathological diagnosis.2-D and 3-D PDI techniques were used to measure uterine smooth muscle tumors at intervals of 6 months.The volume was measured in two ways,1)2-D ultrasound imaging of the three plane of the tumor,measuring the diameter and then calculate the volume;2)3-D volume VOCAL software to get the tumor volume and VI.The average growth rate and VI were examined in the database.Expression of PHH3 and Ki-67 in tumor tissues by immunohistochemical staining S-P and H&E-MI counts of mitotic figures.The ultrasonic score were compared with the three pathological counts.Results 1.There is no difference between the two methods of measuring tumor volume with 2-D and 3-D ultrasound.2.The growth rate was positively correlated with VI(γ = 0.880,p <0.001).The growth rate and VI in the LMSs were significantly different from those in STUMPs,BLMs,MALs and LMs(P <0.05).The growth rate was significantly different between LMs,LMSs and STUMPs(P <0.05).The VI was significant difference between STUMPs,LMSs,BLMs and LMs(P <0.05).The growth rate and VI score of the LMS were significantly higher than those of the other groups.3.The growth rate and VI with PHH3,Ki-67 and H&E-MI showed a significant positive correlation.The growth rate and VI of the LMSs and LMs were positively correlated with the three pathological indexes.4.Comparison of PHH3,Ki-67 and H&E-MI three kinds of pathological indicators showed that the total sample and the five groups of different pathological types of tumor PHH3 and H&E-MI correlation were high.5.The growth rate of 61.25% as a benign and malignant critical value,its sensitivity: 0.952,specificity: 0.943;VI as the threshold value of benign and malignant,sensitivity: 0.952,specificity: 0.975.Conclusions: 1.Two methods of measuring volume by ultrasound are effective.2.There was a positive correlation between the values of the growth rate,VI and PHH3,Ki-67 and H&E-MI counts.3.PHH3 and H&E-MI correlation is higher.4.The growth rate greater than 61.25% and VI greater than 17.8,the possibility of leiomyosarcoma greater.