Study On Desynchronization Of Neural Network Under The Action Of Transcranial Magneto-acoustical Stimulation

The neurodegenerative diseases,such as epilepsy,are one of the major diseases that seriously threaten human health.The main reason is abnormal synchronous discharge of neurons.Transcranial Magneto-Acoustical Stimulation(TMAS)is a new type of brain stimulation technique,which has the advantages of non-invasiveness,large penetration depth and high accuracy.But the application of TMAS has been restricted due to the unclear understanding of its treatment mechanism.To solve the above problems,the Hindmarsh-Rose coupled neural system is established,and the desynchronization mechanism of TMAS is studied by means of numerical simulation.The effect of stimulus parameters on the desynchronization of coupled neural system is evaluated with desynchronization index.The main content is as follows:Firstly,a coupled neuron model is established by using Simulink.The results of desynchronization of coupled neural system under the action of TMAS are obtained.The statistical results show that TMAS can reduce the synchronicity of the coupled neurons.The greater the stimulation intensity of TMAS,the better desynchronization effect of the system.However,if the stimulus intensity is too high,the firing pattern of neurons will be changed.The coupled neurons have selectivity for period and duty ratio,coupled neurons are only sensitive to specific period and specific duty ratio.Secondly,the research object is extended to the neural network,and the desynchronization of neural network under the action of TMAS is studied by computer numerical simulation.The statistical result show that the coupling strength and the probability of adding edge probability are the important factors that contribute to the synchronization of the network.The greater the coupling strength and the adding edge probability,the stronger the synchronicity of the network.It is found that when 10% of the neurons are stimulated by TMAS,the network in a synchronous state can be converted to a desynchronized state.The greater the intensity of the stimulation,the higher the degree of desynchronization.The desynchronization of network is more prominent with small coupling intensity than that with larger coupling intensity.The network is sensitive to period and duty ratio.When other parameters are unchanged,specific period and specific duty ratio can maximize the desynchronization.Finally,according to the experimental results,a comprehensive study of the desynchronization of coupled neurons and the desynchronization of neural network is made.It is found that the desynchronization of coupled neurons is the basis of the desynchronization of neural network desynchronization,and there are many similarities between them.Their amplitude of action potential will not change with the parameters of TMAS.Both coupled neurons and neural network are selective to specific period and specific duty ratio.At the same time,it is found that the neural network achieves a synchronous state with a greater coupling strength than the coupled neurons;The optimal period of the neural network is different from the optimal period of the coupled neurons.The results show that the increase of stimulation intensity is helpful to the desynchronization of coupled neuron system,but too high a stimulus intensity can change the neurons' firing pattern.If the other parameters are constant,there are the best period and the best duty ratio.This study has positive significance for exploring effect mechanisms of TMAS for patients with neurodegenerative diseases,and it can provide theoretical guidance for the application of TMAS in clinical treatment.