Study On The Firing Rhythm Of Neuron Model With Transcranial Magneto-acoustical Stimulation

Transcranial magneto-acoustical stimulation（TMAS）is a novel stimulation technology in which an ultrasonic wave within a magnetostatic field generates an electric current in an area of interest in the brain to modulate neuronal activities.It has the advantage of noninvasive,high spatial resolution and penetration depth.However,the effect of TMAS on the neuronal firing pattern remains unknown.The nerve system plays a very importan role in the modulation and control of the physiologic enginery.The external stimulus are taken by the meurons of nerve system,and coded,propagated and decoded by means of various patterns of nerver fiber discharge,different patterns of discharge reflect the difference of the external stimulus informartion and induce diverse physiological effect.Therefore,in order to further study the effect of the TMAS,the article take the neural model as the research object and discuss the change of the firing rhythm.The article analyzes the progress of neuron model and its firing patterns,also the applicantions of TMAS in the treatment of mental diseases.On this basis,the article study the effect of three types of stimuli（continuous-wave stimuli,pulsed stimuli and sinusoidal stimuli）and different ultrasonic parameters（acoustic intensity,sonication duration,pulse repetition frequency,etc.）with Hodgkin-Huxley neuron model and Chay neuron model on the neuronal firing pattern,and obtain the relationships between external stimulus and firing patterns.The results of simulation show that neuron models can generate rich firing rhythm including the periodic spiking firing pattern,the periodic bursting firing and the chaotic firing with different types of TMAS.The article also focused on analyzing the influence of external stimuli to Ca²⁺ concentration in Chay neuron model.Besides,in view of the open loop state of TMAS,the nonliner control theory is introduced for the synchronization of neuronal action potential,and realize the closed-loop control of TMAS.The adaptive neural network control is proposed to realize synchronization control of HH neuron model.The simulation results prove the effectiveness of the proposed control algorithm.The above research results may help to reveal and explain the biological mechanismof TMAS and to provide a theoretical basis for TMAS in the treatment or rehabilitation of neuropsychiatric disorders.