Analysis On Risk Factors And Clinical Significances In Patients With Pancreatic Cancer

OBJECTIVE: To investigate risk factors and the clinical significances in the patients with pancreatic cancer(PC).METHODS: The clinical data of 936 patients with PC in the Affiliated Hospital of Chongqing Medical University during the past 10 years were retrospectively analyzed,and contemporaneous 832 age and sex-matched cases of non-complicating tumor were collected as the control group.The differences and correlation between the two groups were analyzed retrospectively,including the gender,age,body mass index(BMI),incidence and course of diabetes mellitus(DM),category of hypoglycemic drugs,history of pancreatitis,family history of DM and family history of PC.RESULTS: There were more males than females in PC group,moreover the male proportion was much higher than the female proportion with the age growing.In the PC group,251 cases(26.8%)were complicating DM,which was significantly higher than 13.0% of DM occurrence rate in the control group(P<0.01);in the PC group,new onset DM was up to 14.1%(132/936),which was obviously higher than 3.4% inthe control group(P<0.01).The family history of DM,family history of PC,history of pancreatitis,overweight and obesity were the independent risk factors for PC.The risk of PC in new onset DM patients was increased by4.9 times.Metformin could decrease the risk of developing PC.The time from diagnosed DM to PC in the metformin group was longest[(18.86+3.46)months],which in the non-medication group was shortest [(6.44+1.07)months].CONCLUSION: New onset DM patients with family history of DM,family history of PC,history of pancreatitis,overweight and obese should be vigilant to develop PC.Metformin is a protective factor for PC.For the new onset DM patients,metformin may have effect to delay the occurrence and development of PC.