Research Of Peripheral Chemoreceptor Sensitivity In OSAS Patients

Objectives:The purpose of this study was to evaluate the sensitivity of peripheral chemoreceptor in patients with obstructive sleep apnea syndrome(OSAS)and healthy subjects by hypoxic withdrawal test.The experiments were performed at morning and at bedtime respectively.Analyze the sensitivities of peripheral chemoreceptors in the morning and pre-bedtime time in different groups;the sensitivity of peripheral chemoreceptor at the same time point for different groups of subjects;differences in sensitivity of peripheral chemosensory of different groups between morning and pre-bedtime Methods:20 OSAS patients and 15 healthy subjects participated in the experiment.According to the sex,age,BMI and BSA,they were OSAS patients and healthy subjects respectively.Peripheral chemoreceptor sensitivities were assessed by hypoxia withdrawal test,ie,by administering patients with less than 20 seconds of pure oxygen and calculating their ventilatory reduction(%?V.i),and analyzing intra-and inter-group variability.Results:The peripheral chemoreceptor sensitivity of OSAS patients before bedtime was 21.963±7.281(% ?V.i),which was lower than that of healthy subjects 24.875±4.240,intergroup analysis(p =0.072)p >0.05.The peripheral chemoreceptor sensitivity of OSAS patients 36.654±9.429(% ?V.i)was higher than that of healthy subjects subject25.410±3.722,intergroup analysis(p =0.001)p <0.05;There was no significant difference in peripheral chemoreceptors sensitivities between morning and pre-bedtime in healthy subjects(p =0.431)p >0.05.And there was significant difference in peripheral chemoreceptors sensitivities between morning and pre-bedtime in OSAS patients(p =0.000)p <0.05,there is statistical difference;The OSAS patient group and the healthy subject group,the difference between morning and pre-bedtime was calculated using a statistical basis pre-bedtime as a baseline value.The difference of OSAS patients in peripheral chemoreceptor sensitivities 77.73±16.67(?% ?V.i)between morning and pre-bedtime was significantly different from that of healthy subjects-0.08±5.91(p = 0.000)p <0.05;Conclusions:OSAS patients have peripheral chemoreceptor sensitivity abnormalities,but this respiratory regulation instability may be affected by the patient's own state.Intermittent hypoxia leads to changes in neuroplasticity that result in LTF as well as high loop gain,which make change in peripheral chemoreceptor sensitivities,which is a non-structural pathogenic and aggravating factor of OSAS.