A Study On P16 And HPV16 In Sinonasal Squamous Cell Carcinoma

Objective: The aim of this study is to evaluate the relationship between the expression of P16 and infetion of HPV16 in sinonasal squamous cell carcinoma and its clinical and pathological features,with a view to find reliable indicators for the diagnosis and clinical evaluation of sinonasal squamous cell carcinoma.Method: Fifty-five cases of sinonasal squamous cell carcinoma were collected,twenty cases of nasal in-verted papilloma and thirty cases of nasal polyp were chose as control.The expression of P16 and infection of HPV16 were detected by immunohistochemistry in both experimental group and control group.The positive rate of P16 and the infection rate of HPV16 in sinonasal squamous cell carcinoma and nasal polyps tissues were analyzed to find out if there is significant statistical difference between P16 and HPV16 in the clinical and pathological characteristics of the tumor group.In addition,analyze the relationship between P16 expression and HPV16 infection in sinonasal squamous cell carcinoma.Result: The positive rate of P16 and HPV16 in sinonasal squamous cell carcinoma were significantly higher than the nasal polyp group,the difference was statistically significant(P <0.05);The positive rate of P16 in poorly differentiated tumors was significantly higher than that in well-differentiated tumors.The positive rate of P16 in clinical stages? were significantly higher than those in clinical stages ?,? and ?(P <0.05),while the expression of P16 was not related to the gender,age and tumor primary site(P>0.05).There was no correlation between HPV16 infection and tumor pathological grade,clinical stage,age,sex and primary tumor site(P> 0.05)There was a significant positive correlation between the expression of P16 and HPV16(r = 0.483,P <0.01)in cancer tissues,but not in nasal polyps(P> 0.05).Conclusion: The abnormal expression of P16 and HPV16 infection play an important role in the development of sinonasal squamous cell carcinoma.Differential expression of P16 in clinical progress has a certain meaning;The two may had a synergistic effect.