Study On Gene Polymorphisms Of Mongolian Vascular Dementia In Inner Mongolia Autonomous Region

Objective Five genes associated with cognitive impairment were studied,including articles and backgrounds for PTK2 B,MS4A6A,PICALM,CD33,and SLC24A4 genes,to investigate gene single nucleotide polymorphisms in the Mongolian VaD population of Inner Mongolia Autonomous Region.Methods A case-control study was conducted.A total of 182 Mongolian VaD patients were enrolled from October 2015 to March 2017.Sixty-five Mongolian patients with non-demented stroke were included in the control group.All the investigators who met the conditions performed questionnaires and measurements.After screening the questionnaire and completing the questionnaire,the peripheral blood was extracted using PCR and SNPscanTM multiple SNP genotyping.The frequency distribution of different alleles was compared,and SPSS18.0 statistical software was used for statistical analysis and analysis.Results(1)There was no significant difference in gender,age,smoking history,drinking history,hypertension,and coronary heart disease between the Mongolian VaD group and Mongolian non-demented stroke group(P>0.05).);(2)In the logistic regression analysis after correction of clinical phenotype,rs10498633 was of completely significant significance.Mongolian VaD Risk related(OR: 3.009,95% CI: 1.326~6.823),allele G may increase the risk of VaD(OR: 2.656,95% CI: 1.228~5.746);(3)PTK2B gene rrs28834970 locus,MS4A6 A gene The rs610932 locus,PICALM gene rs3851179 locus,and CD33 locus rs3865444 were not significantly different(P>0.05).Conclusion(1)In a small sample of Mongolian VaD population,the SLC24A4 gene rs10498633 locus may be associated with the risk of VaD,allele G may increase the risk of Mongolian VaD;(2)PTK2B gene rs28834970 locus,MS4A6 A locus rs610932 locus,There was no significant difference in the risk of PICALM gene rs3851179,CD33 gene rs3865444 and VaD.