| ObjectivesTo explore the characteristics of Magnetoencephalography(MEG)power spectrum and functional connectivity of adolescent major depressive disorder(MDD)on first episode,to explore the effect of cortisol level on adolescent MDD on first episode,and to explore the correlation between brain function and cortisol of adolescent MDD.MethodsA clinical control trial was designed.MEG power spectrum analysis,source coherence analysis,and graph theory was used to compute brain spectral power distribution(SPD)and functional connectivity.Statistical methods were used to analyze the differences between patients group and healthy control group,and the correlation between brain function and cortisol in patients.Result(1)Compared with healthy control group,on resting state,in delta band patients group was detected higher power on left parietal lobe(P=0.018<0.05),right temporal lobe(P=0.026<0.05),right parietal lobe(P=0.006<0.01).In theta band the power was increased on right temporal lobe(P=0.004<0.01),on right occipital lobe(P=0.011<0.05).In alpha band the power was increased on left occipital lobe(P=0.035<0.05)and right occipital lobe(P=0.008<0.01).In beta band the power was higher on right central area(P=0.024<0.05)and right occipital lobe(P=0.020<0.05).The differences were significant.Power in delta band on the right temporal lobe was related to HAMD-24 total score(r=0.572,P=0.016<0.05)and sense of despair factor(r=0.505,P=0.039<0.05)respectively.Power in alpha band on the left occipital was related to weightfactor(r=-0.553,P=0.021<0.05).The correlations were significant.(2)Compared with control group,at theta band brain functional connectivity network total connections was increased in patients group(P=0.005<0.01),hub mean was increased(P=0.009<0.01).Both differences were significant.At beta band,total connections was increased(P=0.003<0.01),path mean was increased in patients group(P=0.049<0.05).Both differences were significant.Clustering coefficient mean was more than one in both groups.At theta band,total connections was significant positively related to HAMD-24 total score(r=0.734,P=0.004<0.01),retardation factor(r=0.669,P=0.012<0.05),sleep disturbance factor(r=0.704,P=0.007<0.01),and sense of despair item(r=0.595,P=0.032<0.05);path mean was significant positively related to total score(r=0.723,P=0.005<0.01),anxiety factor(r=0.565,P=0.044<0.05),cognition factor(r=0.623,P=0.023<0.05),and sense of despair item(r=0.700,P=0.008<0.01).At beta band,total connections was significant negatively related to cognition factor(r=-0.589,P=0.034<0.05);path mean was significant negatively related to retardation factor(r=-0.629,P=0.021<0.05).(3)There was no significant differences between two groups about blood cortisol level.No significant correlation was found between cortisol level and HAMD-24.(4)In patients group,the power of left frontal lobe at theta band was negatively related to blood cortisol level(r=-0.700,P=0.017<0.05).At alpha band,there were significant correlations between power of left central area(r=-0.617,P=0.043<0.05)and cortisol level.At delta band,patients group brain functional network total connections(r=-0.700,P=0.016<0.05),path mean(r=-0.700,P=0.016<0.05)were negatively correlated with cortisol level respectively.At beta band,patients group brain functional network total connections(r=-0.836,P=0.001<0.01),hub mean(r=-0.648,P=0.031<0.05)were negatively correlated with cortisol level respectively.These correlations were significant.ConclusionThe MEG power spectrum and functional connectivity of adolescent MDD on first episode had been changed.Cortisol wasn't related to adolescent MDD straightly.Cortisol may have an effect on brain function of adolescent MDD. |
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