Study On The Active Ingredient And Pharmacological Action Of Lysimachia Christinae Hance

Lysimachia christinae Hance is a dry whole grass,There is a certain difference in the pharmacodynamics,pharmacological action and function of Lysimachia christinae Hance.This experiment by Hydrocotyle sibthorpioides Lam????Lysimachia christinae Hance???alcohol extract and four kinds of solvent extraction parts parts?petroleum ether A,ethyl acetate B,chloroform parts C,n-butyl alcohol D,water E?comparative study pharmacological experiment.?1?Wistar rat bile duct drainage,determination of bile content,cholesterol,bile acid,bilirubin content and oxygen consumption after administration?VO₂?,Carbon dioxide production?VCO₂?,respiratory exchange rate?RER?,energy consumption?EE?.Conclusion:?-D best promote the secretion of bile;?-B??-B promote the effective active site of cholesterol secretion;?-A??-C promote the secretion of bile acid active site;?-A??-C??-D??-C promote the secretion of bilirubin effective active site;???-A??-B??-C??-D??-E??-A??-B??-C??-D??-E were significantly promote oxygen consumption;?-B significantly increased respiratory co2 in rats;???-A??-D??-C can significantly improve respiratory exchange rate in rats;?-B significantly increase energy consumption.?2?MDA,ALT,AST,organ index,MG and Glycogen were determined by acute liver injury in KM mice.Conclusion:By reducing the activity of MDA,?-B??-B??-D;By reducing the activity of ALT,?-B??-C;By reducing the activity of AST?-C??-C;?????-B significantly reduce the liver index;???-C significantly reduced spleen index;Elevated MG active site for?-D??-A;The active site of Glycogen was elevated to?-C??-B??-D.?3????-B had a significant inhibition of mouse auricle swelling caused by xylene,the inhibition rate was 25.51%,25.51%respectively,?-D has a significant inhibitory effect,the swelling inhibition rate was37.91%.?of mouse auricle swelling caused by xylene has significant inhibitory effect,the inhibition rate of 30.7%,?-B has significant inhibitory effect,the swelling inhibition rate was 28.65%?4?In this paper,the antimicrobial experiments of 10 kinds of acute cholecystitis were studied.Conclusion:For acute cholecystitis pathogenic bacteria,staphylococcus aureus,?and?,the extract and extraction sites have a very significant inhibitory effect on them;The bacteriostasis of pseudomonas aeruginosa was very significant of???-C??-B??-D;The antibacterial action of proteobacterium is remarkable of?-A??-B??-C??-D??-A??-B;?-B??-D??-E??-E??-D of streptococcus faecalis very significant bacteriostatic action;???-A??-C??-B??-C??-D??-E of E.coli very significant bacteriostatic action;???-A??-B??-C??-D??-E????-E??-A??-C??-B of aeroenterobacter very significant bacteriostatic action;For sewer enterobacter sewer subspecies,besides?bacteriostasis to its significant,the rest of the drug group bacteriostasis significantly;?-A??-B??-D??-E??-A??-B of Klebsiella.very significant bacteriostatic action;For pneumonia klebsiella pneumonia subspecies,except?-B,?-A??-D for their remarkable bacteriostasis,the rest of the group is extremely remarkable bacteriostasis.?5??and?minimal inhibitory concentrations?mic?of acute cholecystitis pathogenic bacteria were similar,?on gas enterbacteriaceae minimum bacteriostatic concentration of 125 ng/ml,?-E radical of streptococcus faecalis minimum bacteriostatic concentration is 93.75 ng/ml,?-A of staphylococcus aureus,pseudomonas aeruginosa minimum bacteriostatic concentration is 6.875 ng/ml,?-C of gas enterbacteriaceae,sewer enterobacter sewer subspecies,excrement enterococcus,pneumonia klebsiella pneumonia subspecies and the minimum bacteriostasis concentration,were 7.5 ng/ml,?-B of escherichia coli,klebsiella acid minimum bacteriostatic concentration,were 10.625 ng/ml,?-D of pseudomonas aeruginosa minimum bacteriostatic concentration,7.5 ng/ml;?alcohol extract of streptococcus faecalis minimum bacteriostatic concentration of 125 ng/ml,?-E radical to staphylococcus aureus minimum bacteriostatic concentration,93.75 ng/ml,?-A of staphylococcus aureus,proteus mirabilis,escherichia coli,enterobacter,produce acid product gas klebsiella minimum bacteriostatic concentration,were 6.875 ng/ml,?-C of pneumonia klebsiella pneumonia subspecies and the minimum bacteriostasis concentration,8.125 ng/ml,?-B of staphylococcus aureus,proteus,enterobacter,produce acid product gas klebsiella minimum bacteriostatic concentration,were10.625 ng/ml,?-D of staphylococcus aureus,pseudomonas aeruginosa,streptococcus faecalis,e.coli,gas enterbacteriaceae and sewer enterobacter sewer subspecies,produce acid klebsiella minimum bacteriostatic concentration,were 16.25 ng/ml.?6?This experiment through?and?and discussed the extraction parts pharmacological effect,to determine the effect and location of the liver and liver of?and?,and to provide a certain basis for chemical separation and clinical guidance.