The Effect Of Repetitive Transcranial Magnetic Stimulation On Cytokines In Depression Patients

Objective:To clarify the effect of the combination of antidepressant drugs with repetitive transcranial magnetic stimulation and simple antidepressant drugs in Major Depressive Disorder,and the correlation between cytokines and Major Depressive Disorder.Method:30 cases of patients with antidepressant drugs combined repetitive transcranial magnetic stimulation were enrolled as experimentalgroup(A group),while 30 cases of patients with simple antidepressants drugs as controlgroup(B group).Collect general information of patients as well as the HAMD scoring results collection and assessment(include pre-treatment and post-treatment);And the levels of interlukin-1?(IL-1?),interlukin-4(IL-4),interlukin-6(IL-6),interlukin-10(IL-10)and Tumor Necrosis Factor-alpha(TNF-?)in serum were measured by ELISA.Spearman correlation was used to analyze the correlation between the level of cytokines and and Hamilton Depression Scale(HAMD)score.Result:1.60 patients all completed the experiment with no fall off,there is no significant difference(P>0.05)in the level of age,gender,education,and course of disease of both groups.2.Before treatment,the difference between the two groups of HAMD(include total scores and each component scores)had no significant difference(P>0.05).After treatment the scores of the two groups all decreased more(P<0.05),and the experimentalgroup was better improved than the controlgroup in total scoreand the scores of depression,work and interest,difficulty in falling asleep,deep sleep,early awakening,and agitation,while the control group's score of systemic symptoms was better improved than the experimental group,differencewas statistically significant(P<0.05).The difference of effective rate(respectively 93.3% and 70%)was statistically significant(P<0.05).3.There were no statistically significant differences between the the levels of cytokines of the two groups(P>0.05)before treatment.The experimental group's levels of IL-1? and TNF-? decreased more than the control group,while the level of IL-4,IL-10 increased more than the control group,and the difference was statistically significant(P<0.05).The differences between the two groups of the level of IL-6 were too small to be statistically significant.4.Spearman correlation analysis showed the level of IL-1? was positively correlated with suicide and anxiety(P<0.05);IL-4 was negatively correlated with early awakening and depression mood(P<0.05).The level of IL-10 was negatively correlated with difficulty in falling asleep and systemic symptoms(P<0.05).TNF-? was negatively correlated with depression mood and suicide(P<0.05).There is no significant correlation between IL-6 and cytokine.Conclusion:Inflammatory factors may involve in the occurrence and development of depression.Compared to simple antidepressants,depressive symptoms canbe remissed by antidepressants and repetitive transcranial magnetic stimulation,antiinflammatory cytokines were significantly increased and inflammatory cytokines decreased significantly.Patients with severe suicidal ideation and sleep disorder can consider combined repeated transcranial magnetic therapy to rapidly improve symptoms and gain time for systematic drug therapy.