| Purpose:To investigate the correlation between carotid plaque formation and stroke risk factors in patients with ischemic stroke(Wind-Stagnation),to determine the risk factors of carotid plaque formation,and to compare the distribution of risk factors related to the nature of plaque.A hierarchical analysis of the risk factors for the formation of different types of carotid plaques provides clinical data for the prevention of the formation of carotid plaques and indirectly reduces the incidence of stroke by controlling the formation of carotid plaques.Method:Select outpatients and inpatients from the Affiliated Hospital of Changchun University of Traditional Chinese Medicine between January 2017 and December 2017,and select all patients who meet the 2016 Chinese guidelines for the diagnosis and treatment of cerebrovascular disease and the consensus diagnosis of cerebral infarction,and then according to the Chinese Society of Chinese Medicine.The diagnostic standards for stroke in the guidelines for diagnosis and treatment of common diseases of traditional Chinese medicine(TCM disorders)were published to screen out patients who meet the diagnosis.Chinese medicine syndromes are determined by referring to the Clinical Guiding Principles for New Drugs of Traditional Chinese Medicine.After a standard screening of the Nasal row,821 patients with ischemic stroke(Wind-Stagnation)were included.Carotid artery intima-media thickness(IMT)was measured by carotid ultrasonography.Patients were classified according to IMT measurements.Carotid atherosclerosis with plaque formation in unstable plaque group(unstable plaque group)in 588 cases(71.62%),carotid atherosclerosis with plaque formation in stable plaque group(stabilized plaque group)149 Cases(18.15%),and carotid atherosclerosis without plaque formation group(no plaque group)84 cases(10.23%).Cross-sectional study methods were used to count general patient data,physical examinations,past medical history,personal history,family history,electrocardiogram,and laboratory tests.Finally,multivariate Logistic regression analysis was used to analyze the correlation between carotid artery plaque formation and risk factors for stroke.There were no significant differences between the risk factors in the chi-square test,and descriptive qualitative data was used to analyze the differences in risk factors between different groups.Use frequency distribution to compare risk distribution factors.Result: 1.Comparison of the frequency distribution of single influencing factors: Among the 821 patients with ischemic stroke(Wind-Stagnation Syndrome),the top three were hypertension(70.52%),hyperlipidemia(66.38%),and smoking.65.41%.2.Using multivariate Logistic regression analysis,the independent risk factors for carotid plaque formation were hypertension(OR=3.797,95%CI: 2.076-6.947,P<0.01)and dyslipidemia(OR=6.465).95% CI: 3.427-12.196,P<0.01),Diabetes mellitus(OR=11.155,95% CI: 5.423-22.949,P<0.01),and Smoking(OR=12.207,95% CI:6.160-24.192,P<0.01)Among them,the smoking group had the largest OR value,so it is believed that smoking among these risk factors has the greatest impact on carotid plaque formation.3.(1)The differences in the distribution of hypertension between the more unstable plaque group and the stable plaque group were found to be ?2=83.526,P<0.001,so the two groups of data can be compared.According to the statistical description of qualitative data,the odds ratio ratio OR=4.62,which is the independent risk factor,is 4.62 times that of the unstable type of carotid artery unstable plaque in the hypertension group.(2)The difference in distribution of dyslipidemia between the two groups was relatively unstable plaque group and stable plaque group resulted in ?2=19.163,P<0.01,so the two groups of data can be compared.According to the statistical description of qualitative data,the odds ratio ratio OR = 2.28,which is the independent risk factor,is 2.28 times that of the stable type in patients with unstable carotid plaque in the dyslipidemia group.(3)The differences in the distribution of diabetes between the more unstable plaque group and the stable plaque group resulted in ?2=65.126,P<0.01,so the two groups of data can be compared.According to the statistical description of qualitative data,the odds ratio OR = 4.41,that is,in the independent risk factors,4.41% of patients with unstable carotid plaque formation in the diabetes group were stable.(4)The difference in smoking distribution between the two groups was relatively unstable plaque group and stable plaque group(2 = 35.587,P <0.01),so the two groups of data can be compared.According to the statistical description of qualitative data,odds ratio OR = 3.01,which is an independent risk factor,was found to be 3.01 times more stable in patients with unstable carotid artery plaques in the smoking group.4.Comparison of risk factors in patients with unstable plaques: The proportion of patients with a history of diabetes was the highest in 10 years,and the proportion of patients with a history of hypertension was the highest in 10-20 years,and the ratio of smokers was the highest in 20 years.The highest proportion of abnormal patients was patients with abnormally elevated LDL cholesterol.Conclusion:Hypertension,diabetes,dyslipidemia,and smoking are closely related to carotid plaque formation and are independent risk factors.Patients with hypertensive disease history in 10-20 years,older smokers,initial diabetes,and abnormally high LDL cholesterol levels were more likely to develop unstable plaques.It is advisable to control these risk factors and to prevent carotid plaque formation based on the distribution of risk factors,thereby reducing the incidence of ischemic stroke. |
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