| Liuwei dihuang fang yuan from the eastern Han zhang zhongjing medical classics "golden chamber".Zhang zhongjing removed the prescription of "jinqi-kidney hi pills" and the two herbs of Guizot,and replaced it with dry ground yellow,named "liuwei dihuang pill".It was composed of six Chinese traditional Chinese medicines,such as cooked ground yellow,fructose corni,yam,rhizome,peonies and poria,etc.,which is called "the probationary of Yin fang".At present,compound preparations,such as the characteristics of pills,contain large amounts of medicine,but they are difficult to disintegrate and affect their absorption.The dropping pills absorb fast,the dissolution time is short,but the load is small.On the basis of this,the new dosage form of Weill Dix pill was developed,and the pill was absorbed by the pill and the length of dropping pills,which made up the deficiency.Compared with the pills,it has short dissolution time and is easy to disintegrate.Compared with the dropping pill,it contains a large amount of medicine,and it can retain the active ingredients of 6 MSG,especially the volatile components and the lipid soluble components,thereby improving the inconvenience of taking and carrying,and improving the curative effect.In this study,the preparation process,quality standard study and preliminary stability study were carried out in the theory of traditional Chinese medicine.This subject is based on the chemical properties and pharmacological action of the effective components of the six herbs in the compound,and with the characteristics of its functional main treatment,the active ingredients of various medicinal materials are retained to the maximum extent,and the orthogonal test method is applied.Through multiple tests,the selection of the extraction process,the selection of the substrate type,the selection of the coolant type,the screening of the drop temperature,the screening of the upper temperature of the coolant,the preparation of the main drug and the matrix,the drop distance and other aspects are studied,and the optimal preparation technology is finally screened out.Using the water extraction method to extract the rare earth yellow,porno,the yam and other scum;An alcohol-sinking method is used to extract the meat.The drying method is vacuum drying,and the best substrate for dropping heart pills is a mixture of PEG10000 and PEG6000.Preparation process:matrix selection PEG4000:PEG6000=1:10 mixed matrix,coolant,dim ethyl silicone oil(10?),drops the head temperature should be 85?,dripping from should be 5cm,determine the main medicine and substrate ratio of 1:2.Study on the quality standard of liuwei dihuang drop heart pills:TLC identification method was used to identify the six ingredients of medicinal ingredients.Using high performance liquid chromatography(HPLC)method for the main effective ingredients wine Cronus,has carried on the system methodology were studies.The average content of the wine was 0.4750 mg/g,and the average content of peony skin was 0.4148 mg/g,and strict quality standards were formulated for the medicinal materials and the finished products,which improved the quality control standards of the product throughout the process.Finally,it is determined that liuwei dihuang drop heart pills,the characters are brown or bright black concentrated pills;The specification is 720 mg/pill;In addition,the short-term stability of the product under acceleration condition and long-term condition is investigated.The results of this research show that the preparation process of Liuwei Dihuang Drip Pill is stable,the quality standard research is comprehensive,the stability results are good,the science is feasible,and the ability to support large-scale production is available. |
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