| Object: Liuwei Dihuang Pill, alternate name Dihuang Pill, comes from key to Therapeutics of Children's Diseases whose author is Qian Yi in song dynasty, and it's modification of prescription is from eight tastes pill from surname cui in synopsis of prescriptions of golden chamber in the Han Dynasty. And then, It becomes the focal point of the Study of Prescription and Herbs in contemporary times as one of the representative prescriptions for invigorating yin because of ingenious principles of treatment and extensive indications. Liuwei Dihuang Pill can be also known as the head of prescription for invigorating yin due to greatness of quantity and extent on relevant researches. Previous relevant researches emphasizes on simply clinical empirical summary and the study of pharmacological experiments owing to the limitation of historical conditions. As a result, lots of basic problems such as the diversified range of indications of Liuwei Dihuang Pill havn't be given affirmative replication, for example, what are the therapeutic mechanism and pathogenesis of Liuwei Dihuang Pill and its associated prescriptions which have the wide applications and eminent effects on treating intractable diseases, and how to know Liuwei Dihuang Pill and its associated prescriptions from the standing of theory and control the flexible differentiation and extensive application of Liuwei Dihuang Pill, as to this, whether or not current theories can generalize the numerous and complicated clinical experiences, and alone can it be clinical and dialectical guides by opening up the new field of curing. Subject this to issue the above, launch to light root of Liuwei Dihuang Pill and add and subtract square manage system of law study, attempt to clear up and summarize systematically its abundant clinical experience that the many doctors accumulate at all times, from the standing of theory, according to the dialectical theory.Method: Subject to the principle that combine classical theory with clinical practice, fully take advantage of the abundant researching documents and extensive clinical cases etc. At all time, regard treating in classical symptoms as the starting point, regard the classification of ZHENG-oriented as the clue, regard the ancient and modern documents as the basis, regard clinical effect as the criterion, regard diagnosis and treatment regularity as leading guidance, ancient and modern medical cases on applying Liuwei Dihuang Pill as the point of penetration, make frequency analysis, factor analysis and cluster analysis from location of diseases, clinical manifestations, etiology and pathogenesis and derivative medicines from abundant experiences on treating of Liuwei Dihuang Pill in ancient and modern times, then according to the trend roughly of statistics, delimit primary and secondary of type of differentiation, finally manage the mutual confirm of the practical clinical and documentary theory, on the basis of analyzing in depth the Liuwei Dihuang Pill and use extensive physiological mechanism, extensively communicate miscellaneous various types of differentiation and sort out systematically extensively to clinical experience in theory.Results: We obtain the following results by mathematical statistics analysis of 629 clinical cases.1.ZHENG-oriented of Liuwei Dihuang Pill and its associated prescriptions should be divided into 7 cluster groups: liver-kidney yin deficiency; kidney yin deficiency; edema due to yang deficiency; deficiency of both qi and yin, body fluid consumption; lung-kidney yin deficiency; heart-spleen -kidney yang deficiency; asthenia excess Heart in interior. The ZHENG-oriented could be extracted 11 common factors into 6 common factors according to accumulative contribution rate: kidney yin deficiency, incoordination between liver and kidney, kidney yang and qi deficiency, lung-kidney deficiency, disharmony of the heart and kidney, spleen-kidney deficiency.2. The characteristics of herbal nature of Liuwei Dihuang Pill and its associated prescriptions are as follows: herb of cold property, warm property and constant property accounted for a very large proportion ( 95.50% ); herb of hot property and cool property accounted for a small proportion (4.50%). The characteristics of herbal channel tropism are as follows: five viscera accounted for a very large proportion(totally 93.38%, Kidney-35.30%;Liver-18.34%; Heart-15.12%; Spleen-14.66%, Lung-9.97%); six hollow viscera accounted for a small proportion(totally6.62%, bladder-4.18% which is the biggest proportion of six hollow viscera).3. The principles of treatment of Liuwei Dihuang Pill and its associated prescriptions should be divided into 12 cluster groups: clearing away heat and nourishing yin, nourishing kidney and liver; nourishing yin and generating body fluid, astringing lung and checking diarrhea; nourishing liver and kidney, nourishing yin and improving eyesight; reinforcing kidney to strengthen essence and arresting discharge; nourishing liver and kidney and strengthening the tendons and bones; nourishing kidney yang and filling essence; warming yang to fluidizing qi and induce diuresis to alleviate edema; nourishing primordial qi; regulating qi and stagnation of qi; arresting seminal emission, tranquilizing and relieving uneasiness; hyperactivity nourishing heart to calm mind; coordinating heart-kidney. The derivative herb could be extracted 6 common factors according to accumulative contribution rate: nourishing kidney yin and arresting seminal emission; nourishing liver and kidney; nourishing kidney yang and relieving stranguria by diuresis; relieving heart and relieving uneasiness; nourishing spleen and kidney; nourishing lung and kidney. Conclusion: Through the summary and mathematical statistics analysis, we obtain the following conclusions.1. The etiological factors of ZHENG-oriented on Dihuang Pill and its associated prescriptions are as follows: congenital deficiencies, acquired missing nourish, oldness to deficiency, chronic disease to deficiency, emotion transfer to damage, overload and exertion.2. The frame of syndrome differentiation and treatment of Dihuang Pill and its associated prescriptions includes the differentiation for syndrome classification, differentiation for treatment classification and critical medication usage.3.The characteristics of indications have great variety; and the method of nourishing the kidney-yin has good-compatibility; Kidney-Qi Pill and its associated prescriptions are parts of Liuwei Dihuang Pill and its associated prescriptions; Dihuang Pill is the central status among Liuwei Dihuang Pill and its associated prescriptions.4.The characteristic of herbal nature of Dihuang Pill and its associated prescriptions mainly includes multiple herb of cold property, warm property and constant property with herb of hot property and cool property. And the characteristic of taste of herb is as follows:excessive sweetish taste in combination with mild, bitter, sour,harsh,saline taste and pungent herbs;The regularity of locations: five viscera is common, kidney is as oriented followed by liver, both heart and spleen are included with lung as well as rare six hollow organs, frequent bladder and stomach.
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