Epidemiological Investigation Of Multiple Myeloma In Jining City

Objective To analyze the clinical data of newly diagnosed multiple myeloma(MM)in Jining in 2015,and to provide the theoretical basis for the epidemiological study of MM.Methods From January 1,2015 to December 31,2015,114 patients with newly diagnosed MM were selected as the subjects in Jining.The date of these research objects are from“cancer reporting system of Jining Disease Control and prevention Center”,hospital information system(HIS)of Second-graded or above Hospitals in Jining,and information system of Jining medical insurance management center.The incidence rate of MM,distribution of gender,age and region,MM clinical stages,types of M protein,primary symptom,and clinical features associated with renal damage were observed in Jining in 2015.Results(1)In 2015,the incidence rate of MM in Jining was 1.38/100 000(the standardized incidence rate of China's population was 1.35/100 000,and the standardized incidence rate of the world population was 1.10/10 million.(2)The male incidence rate of MM was 1.68/100 000,and that of female was 1.14/100 000.The incidence rate of MM between male and female was statistically significant(?2=4.248,P=0.039).(3)The average age of onset in male MM patients was(65.9±9.9)years old,and the females were(65.3±9.8)years old.The difference between them was not statistically significant(t=0.334,P=0.584).(4)The incidence of MM in rural areas was 2.24/100 000,and the incidence of MM in urban areas was 0.59/10 million.There was significant difference between them(?2=41.007,P=0.000).(5)There were 57 patients(50%)with stage ? MM.(6)The primary symptoms of MM were bone pain(32.5%)and weakness(21.9%)at first visit.(7)There were significant differences in hemoglobin,levels of ?2-microglobulin(MG),serum concentration of Ca2+ between normal renal function patients and abnormal renal function patients(?2=4.154,14.233,4.600;P=0.042,0.000,0.032).Conclusions In 2015,the incidence rate of MM was 1.38/100 000 in Jining.The age of onset in Jining was younger than that in Europe and America,and the incidence rate of MM in male was higher than that in female.The incidence rate of MM in rural areas was higher than that in urban areas.The clinical stage of MM patients is usually stage ? at the first visit.Hemoglobin,serum calcium and ?2-MG are closely related to the impairment of renal function in patients with MM.