| Objective: To tentatively explore the theoretical basis of the combination of Zhuang medicine and Thai medicine in insomnia,by analyzing the application of Chinese Zhuang medicine resources and traditional Thai medicine of Thailand on treating insomnia,which is called Niannaonuo in Zhuang medicine.Combining the clinical curative effect observation research and experimental technical index research of Zhuangtaianshen Patch in treating insomnia,with the acupoint joint selection of Zhuangtaianshen group and Zhuang medicine acupoint application therapy which is mainly composed of Zhuang medicine and focusing on tranquilizing Qiaowu(brain is called Qiaowu in Zhuang medicine)under the guidance of the basic theory of Traditional Chinese Medicine and Zhuang medicine,this paper tentatively probes into the clinical curative effect of Zhuangtaianshen acupoint application therapy in insomnia and the mechanism and effect of external treatment on endogenous melatonin in patients' serum.Methods: 1.Clinical research: From July 2016 to January 2018,93 insomnia patients were selected to receive clinical research in the First Affiliated Hospital of Guangxi University of Chinese Medicine and Duqiaoshan Hospital of Rong county.The treatment group(n=31)was treated with Zhuang medicine acupoint application,the Estazolam group(n=31)was treated with routine Estazolam tablets,and the combined treatment group(n=31)was treated with Zhuang medicine acupoint application combined with Estazolam tablets.All three groups took 28 days as a course of treatment,and their clinical efficacy,PSQI score of Pittsburgh Sleep Quality Index scale and Epworth score of the Epworth Sleeping Scale were statistically analyzed.2.Experimental research: In the acupoint application treatment group,20 patients were randomly selected as the experimental group,and 20 healthy people were selected as the blank control group.Enzyme-Linked Immunosorbent Assay(ELISA)was used to detect concentrations of melatonin(MT),gamma-aminobutyric acid(GABA)and dopamine(DA).The content changes of three technical indicators before and after treatment were analyzed,and SPSS 22.0 was used for statistical analysis.Results: Among 93 insomnia patients,3 cases were excluded and removed.After clinical treatment,the total effective rate in the treatment group was 73.33%,that in the Estazolam group was 76.67%,and in the combined treatment group was 86.67%.After treatment,PSQI total score and Epworth score of three groups of insomnia patients decreased,which showed significant difference compared with those before treatment(p<0.01).After acupoint application therapy,the MT and GABA concentration in experimental group increased,while DA concentration decreased,which showed a trend of change to some extent.Compared with that before treatment,there was significant difference(p<0.01).Conclusion: Zhuangtaianshen Patch has a definite curative effect on insomnia through acupoint application,which is feasible and easy to be recognized and accepted by patients.It can improve the sleep quality of insomnia patients to some extent.Its mechanism may be that exogenous melatonin can enhance its Plasma Concentration by external treatment of acupoints,thus improving the overall level of drug regulating organism and organism regulating endogenous melatonin,which is worthy of clinical popularization and application. |
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