Correlation Analysis Of Wavefront Aberrations And Retinal Image Quality In Different Types Of Cataracts

Objective:To explore the correlation between the wavefront aberration characteristics of different types of early cataract and the quality of retina imaging,so as to provide a reference for selecting the best time for cataract surgery.Medthods:One hundred and three patients(103 eyes)with age-related cataract were recruited from July to November 2016 at Affiliated Hospital,Yanbian University.The subjects had a spherical equivalent(SE)between +3.00 and-3.00 diopters(D),and best corrected visual acuity(BCVA)better than 0.3 logMAR units.Forty-one eyes with mild nuclear cataract,33 eyes with mild cortical cataract,and 29 eyes with mild posterior subcapsular cataract were examined.In each group,wavefront aberrations in the entire eye and in the internal optics and retinal image quality were measured using a raytracing aberrometer(iTrace,Tracey Technologies,Houston,TX,USA).In addition,nuclear lens density(0 to 100 optical density units)was determined using the Scheimpflug images(Pentacam(?),Oculus,Germany).Results:1.In this study,103 eyes of 103 patients(53men,50 women)were evaluated.The mean age of the patients was 65.8 ± 6.3 years(range 52 to 76 years).There were no statistically significant differences between groups in age,best spectacle-corrected visual acuity(BSCVA)and comeal asphericity(Q-values)(P>0.05).2.There was no difference in corneal aberrations among the groups(P>0.05).In the entire eye and internal optics of the eye,the cortical and nuclear cataract groups had statistically significantly lower total HOA than the posterior subcapsular group(P<0.05).The cortical cataract group had statistically significantly higher coma-like aberrations than the nuclear and posterior subcapsular groups(P<0.05).The nuclear cataract group had statistically significantly lower spherical aberrations(negative shift)than the other two groups(P<0.001 and P<0.001,respectively).3.Higher-order Zernike coefficients of the internal optics(3rd to 6th order)in the three groups.The nuclear cataract group had statistically significantly lower internal spherical aberrations(Zernike coefficient,Z4.0 and Z6.0)than the.cortical and posterior subcapsular cataract groups(P<0.001 and P<0.001,respectively).The cortical cataract groups had statistically significantly higher trefoil(Z3.-3)than the other two groups(P<0.05).Other HO As showed no significant differences.4.The MTF curves under the 6 mm pupil in cortical,nuclear,and posterior subcapsular cataract groups.The posterior subcapsular cataract group had lower performance than cortical and nuclear cataract groups at 5 and 10 cpd(P<0.001 and P<0.001,respectively).No statistically significant difference was found between the cortical and nuclear cataract groups at all spatial frequencies.5.The relationships between nuclear lens density and internal optics aberrations in the nuclear cataract group.The RMS of HOAs,coma,and trefoil had no significant correlation with the nuclear lens density(P>0.05).However,as the nuclear lens density increased,the spherical aberration in the internal optics of the eye showed a negative shift(P<0.05).Conclusions:The wavefront aberration can be used to quantitatively analyze the effect of different lens opacity types and density on the quality of retinal imaging in early cataract patients.The evaluation of the optical characteristics of the lens wavefront in early cataract patients can effectively evaluate the visual function of the early cataract patients,and can be used as the basis for selecting the best operation time.