The Distribution Of Tcm Syndromes Of Non-small Cell Lung Cancer And Its Correlation With EGFR And ALK Gene Expression

1 Objective:Preliminary study of primary lung cancer syndromes distribution,at the same time with EGFR,ALK,the staging,pathological type,tumor markers and other modern objective indexes for research object,study its correlation with lung cancer diseases,to provide the basis for clinical treatment.2 Methods:A prospective clinical case study method was used to design and formulate a case information collection table for patients with lung cancer(see the attached table).In strict accordance with the inclusion criteria and exclusion criteria for case selection,a detailed record of the patient’s name,gender,age,symptoms,tongue and pulse,EGFR,ALK gene expression and pathological type,TNM staging and tumor related international index,after brief treatment etc.,were Karnofsky score.And according to the related diagnostic criteria,the selected cases are differentiated and classified,the syndrome differentiation is first identified,and then the single syndrome is added to form the method of complex syndrome.the EGFR and ALK gene detection patients were analyzed to explore the correlation between the distribution of TCM syndromes and the expression of EGFR and ALK genes in lung cancer.3 Results:In this study,120 cases were collected in accordance with the inclusion criteria.After the analysis of the above research methods,the specific results were as follows:3.1 NSCLC patients with TCM syndrome type distribution: Among the 120 cases of non-small cell lung cancer,TCM syndrome statistics.A total of 23 species.The total number of cases with a single card is 30 cases,accounting for 25% of the total cases.There were 53 cases with two single syndromes,accounting for 44.17% of the total number of cases.The total number of cases of three or more single syndromes was 37,accounting for 30.83% of the total number of cases,and the distribution of qi deficiency syndrome,blood stasis syndrome and phlegm-wet syndrome had obvious advantages.less than 12 card type covers 80% of the total number of cases: Qi deficiency and phlegm dampness and blood stasis;Qi deficiency;Qi deficiency and blood stasis;Qi deficiency and phlegm;blood stasis and phlegm;two Qi and yin deficiency syndrome;Qi deficiency and qi stagnation,blood stasis and qi stagnation syndrome of deficiency of yin and Yang;two;blood stasis;Qi deficiency and yin deficiency,qi stagnation and blood stasis syndrome;phlegm dampness syndrome.The total number of cases accounted for 12.50%,10.83%,10%,9.17%,8.33%,7.50%,7.50%,4.17%,3.33%,3.33%,3.33%,3.33%.3.2 TCM syndrome type and TNM stages of relationship: Ⅰ,in the majority with empirical stage II patients,a total of 28 cases(64.23%),and given priority to with blood stasis and phlegm wet.III.In patients with stage IV,there were a lot of false inclusions(67.39%)and deficiency syndrome(32.61%),among which the deficiency syndrome was mainly manifested as qi deficiency and deficiency of qi and Yin,and the deficiency of false evidence was found in qi deficiency and phlegm dampness and blood stasis.There was a significant correlation between the TCM syndromes of NSCLC patients and TNM staging(P= 0.002).3.3 The relationship between TCM syndromes and pathological types: the highest frequency of scaly and adenocarcinoma syndromes are qi deficiency syndrome,blood stasis syndrome and phlegm dampness syndrome.There was no significant correlation between TCM syndrome type and pathological type of NSCLC(P= 0.445).3.4 The most common molecular mutation type EGFR gene mutation type accounted for 45%,between different TCM Syndromes of NSCLC patients had significant difference between the mutant EGFR gene,EGFR gene mutation rate(64.81%)was the highest in patients with false inclusion syndrome(NSCLC).Secondly,the deficiency syndrome(29.63%)and empirical evidence(5.56%);EML4-ALK mutation between different TCM Syndromes of NSCLC patients there was no statistically significant difference.Conclusion:4.1 In the TCM syndromes of NSCLC,the deficiency syndrome is mostly seen in "qi deficiency",and the evidence is mainly "phlegm-dampness and blood stasis".Therefore,"qi deficiency,phlegm dampness and blood stasis" are the most common syndromes of NSCLC,and also the basic pathogenesis of NSCLC,which provides theoretical basis for the treatment of NSCLC.4.2 There is a clear correlation between TCM syndrome type and TNM staging,Ⅰ,ⅡNSCLC patients with empirical,with TNM staging from early to late progress,pathogenic 1 its gradually from empirical to factors,pure virtual card development,Ⅲ,Ⅳ period in patients with multiple factors and pure deficiency syndrome.4.3 There was no significant correlation between TCM syndrome type and pathological type.4.4 High EGFR gene mutation was found in patients with NSCLC,and the mutation rate was highest in EGFR 19 exon and 21 exons.In NSCLC patients,EGFR mutation rate was increased in order of evidence,deficiency and false evidence,which can be used as an indicator to reflect the actual condition of patients with lung cancer.The mutation rate of eml4-alk in patients with NSCLC was low,and there was no significant correlation between TCM syndromes and eml4-alk mutations.