Clinical Study On Splenic Wet Method Was Used For The Treatment Of Spleen Deficiency And Dampness In Wilson's Disease

Objectives:(1)To compare the clinical efficacy and safety of drug administration of WD patients by observing the changes in the related indicators of spleen deficiency and dampness aheat type.(2)By discussing WD and "spleen function" and the study of the relationship between effect index changes,the analysis of "treated from the spleen" the necessity of WD,for liver degeneration of TCM clinical syndrome differentiation to provide certain reference and the diagnosis and treatment.Methods:Selection criteria for the diagnosis of conform to the degeneration of the liver,64 cases,after admission condition classification reference improved Goldstein classification method,random points in the treatment group and control group,two groups,32 cases in control group liver soup oral and 2 thiol propyl sulfonic acid sodium static drop(DMPS),on the basis of the control group and treatment group with spleen and efficacy of traditional Chinese medicines,since the quasi joint DMPS spleen and liver soup treatment,a total of 4 sessions,followed up for a week,observe the two groups before and after treatment in patients with the clinical curative effect,UWDRS total value,UWDRS I and UWDRS II score,TCM syndrome integral,KPS score,physical and chemical index and clinical safety index,the change of adverse reactions.Results:(1)evaluation of total clinical efficacy: the total effective rate of the two groups was different(P<0.05).(2)changes in TCM syndrome differentiation: 2 courses: no difference between the two groups(P>0.05);At the end of the treatment group,there was a difference(P<0.01)between the treatment group and the end group before and after treatment,and there was a significant difference(P<0.01)between the group and the control group.(3)UWDRS total score,UWDRS I and UWDRS II score: at the end of 2 courses,there was no statistical significance(P>0.05).After 4 courses of treatment,the score decreased,and the treatment group decreased significantly(P<0.05).The UWDRS II score of the treatment group was significantly different(P<0.01)compared with the treatment before treatment,and the decrease of the treatment group was remarkable better than that in the control group,and there was significant difference after comparison(P<0.01).(4)KPS score changes: there was no difference in KPS scores between the two groups before treatment(P>0.05).The KPS score was increased between the treatment group and the pretreatment group(P<0.05),and the control group was no different from the treatment before treatment(P>0.05).At the end of the 4 course of treatment,the comparison between the treatment group and the treatment group before and after treatment was increased(P<0.01),and the difference was statistically significant.Control group 4 at the end of the course of treatment compared with before treatment and 2 at the end of the treatment group KPS score increases,the difference was statistically significant(P<0.05),treatment group KPS score increased significantly compared with control group,with differences(P<0.05).(5)The change of urine copper in 24 hours: before the treatment,two groups of 24 hour urine copper value was no difference(P>0.05),two after the treatment: the treatment group and control group in the urine copper values are rising,two groups of 24 hour urine copper value rise level no difference(P>0.05);At the end of 4 courses: two groups of 24 hours of urine copper were higher than those in the treatment group before and after treatment,and the treatment group was significantly higher than the control group(P<0.01).(6)serum copper level,serum copper oxidase,and serum copper-blue protein: there was no significant difference between the treatment group and the pre-treatment group(P >0.05).(7)the changes of gastric secrete element and pepsin: at the end of the period oftreatment: treatment group of pepsin,stomach gastrin-releasing value compared with the within group before treatment and after treatment comparison between control way were higher(P<0.05),no obvious change the control indicators before and after the treatment,two groups after treatment scores more significant difference(P<0.01).(8)drug safety: before and after treatment,two groups of patients safety indexes not seen obvious abnormity,two group of patients with adverse reaction difference no difference(P>0.05),the discontinuation after one week,two groups of patients with adverse reactions basic disappeared,and the comparison of two groups has no statistical significance(P>0.05).Conclusion:(1)"spleen and liver soup" joint DMPS treatment of syndrome of liver degeneration of pixu(spleen deficient)clinical effect is better than that of hepatic bean soup combined DMPS,reveals the "treated from the spleen liver degeneration of the feasibility and clinical significance of WD provides a new treatment method for clinical intervention and train of thought.(2)The spleen of WD soup has good drug safety.