The Molecular Epidemiology Of Rotavirus Circulating In Chongqing,2011-2015

Group A rotavirus is one of the major causes of acute viral gastroenteritis in infants and young children worldwide,95%of chilidren were infected with rotavirus before the age of five,leading to serious social and economic burden.There is no specific treatment for rotavirus diarrhea,vaccination is the most efficient methods to prevent and control rotavirus infection.The prevalence of rotavirus was obvious regionality,the main epidemic strains are changing over time.The epidemiological surveillance of rotavirus is important for understanding the evolution of rotavirus and the development of highly efficient rotavirus vaccines.In the present study,a total of 2236 diarrhea samples were collected,RV was confirmed in 681(30.46%)out of 2236,388 cases were male and 293 cases were female.Among the 681 patients,the highest rate of rotavirus detection was 42.32%in children aged 12-24 months.Children under 2 years account for 89.28%of all rotavirus diarrhea.Rotavirus was prevalence from October to January.The predominate G-genotype shift from G1 to G9 in 2011-2015,while P[8]was always the main P-genotype.G9P[8]was the most common G/P combinations,follow by G1P[8],G3P[8]and G2P[4].There is no reassortment between human rotaivirus and other animal rotavirus among 681 rotavirus-positive sample.However,using whole genomic analysis,we investigated 1 rare G1P[4]human rotavirus strains,the genotype constrllations G1P[4]has been designated I2-R1-C1-M1-A2-N2-T1-E1-H1.Results suggest multiple segments reassortment between Wa-like and DS-1-like strains.In summary,the epidemiology of rotavirus in Chongqing is complicated and changeable;we should strengtheded the monitor of rotavirus infection to provide reference for the development and introducion of vaccine.