To Study The Therapeutic Effect And Mechanism Of Bletilla Striata On Silicosis

Objective:By means of modern pharmacology,To study the therapeutic effect and mechanism of Bletilla striata on silicosisMethods:?Using alcohol extraction and water extraction of Bletilla sfrata(Thunb.)Reiehb.f method to extract the white and different parts of the preliminary analysis of the main ingredients.?Preliminary can determine the efficacy of treatment of silicosis and its role in parts.?Determine the white and the efficacy of treatment of silicosis dose and its mechanism of action.Results:Bletilla striata extract enrichment of polyamide parts contained p-hydroxy benzaldehyde,Philippine and dihydrogen compounds;White and aqueous extract polysaccharide components is mainly composed of glucose and mannoseEffective for the treatment of silicosis rats parts mainly for enrichment of alcohol extraction of polyamide parts,its effective dosage is 30 mg/kg,the parts can reduce the lung index,reduce the hydroxyproline content in the body,reduce the content of MDA,NO oxidation system,reduce the cell factor system of NF-kB,IL-1?,TGF-?1,PDGF,TNF-?,CD8+content in the immune system and increase the content of SOD in the oxidation system for treatment of silicosisConclusion:?White and alcohol extract enrichment of polyamide parts contained p-hydroxy benzaldehyde,Philippine class and two hydrogen compounds;White and aqueous extract polysaccharide components is mainly composed of glucose and mannose.?Treatment of silicosis rats effectively parts for alcohol extract enrichment of polyamide? Bletilla sfriata(Thunb.)Reiehb.f is the mechanism of effect for the treatment of silicosis polyamide enrichment part by adjusting the factors of oxidation system;Adjust some cytokines in vivo as well as the effect on immune cells and play a role for the treatment of silicosis.Conclusion white and able to treatment of silicosis and its main efficacy site for the white and the alcohol extract of polyamide enrichment area of small molecule compounds.