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The Research Of Quality Analysis Of Shenkang Injertion

Posted on:2016-07-01Degree:MasterType:Thesis
Country:ChinaCandidate:J T YuanFull Text:PDF
GTID:2404330464956345Subject:Chinese materia medica
Abstract/Summary:PDF Full Text Request
Shenkang injection is made rhubarb,Salvia,safflower,Astragalus four flavor ingredients through a series of craft,made of traditional Chinese medicine injections.Turbidity has Jiangni,Yiqihuoxue Tongfu dampness and other effects,is a commonly used drug for the treatment of chronic renal failure.In this paper,safety,efficacy and operability of principles Shenkang injection current quality analysis methods of analysis and systematic research.Existing research shows that the main ingredient prescription rhubarb anthraquinone substances,Shenkang injection efficacy plays a major role in the determination of the existing standard rhubarb composition is divided into two parts,one another TLC HPLC and content aspects.Two ways of prescription rhubarb qualitative and quantitative quality control,but there is a complicated operation existing methods,standards,high consumption,the result is not precise enough problems.TLC and determination methods described herein rhubarb were re-examined by HPLC.TLC method which changes the test solution preparation method is consistent with the loss of TLC method for preparing the test solution Salvia,while the reference method for the control of TLC changed to control medicine as control of thin layer chromatographic identification.Determination,using a more advanced,"a multi-test assessment" method,five anthraquinones aloe-emodin injection for Shenkang rhubarb,rhubarb acid,emodin,rhubarb,Physcion,select emodin as an internal matter,get emodin relative correction factor for another four substances by experiment,the actual measurement,only by emodin standard materials Shenkang injection emodin were determined by additional correction factor can be calculated the content of the four substances.In this paper,the scientific statistical methods to obtain the relative correction factor,and the method is a series of methodological study results show that the method reliable and durable.In this paper,for the determination of rhubarb,"a more measured assessment" method content Shenkang injection,simplifying the experimental method,results are accurate.A reference can be realized using only the detection of five anthraquinones for production testing saves a lot of costs,and "a more measured assessment" application and compound injection of detection is the first time,for the method in other varieties of Chinese medicine formulations detection applications experience.Research methods in this article there is only measured and the content of the same class of chemical substances."a more measured assessment" method,the next hope to conduct research on the different types of chemical substances,"a more measured assessment" method.This allows you the maximum extent possible to resolve the type reference and insufficient quantity of supply.All this research is more simple,rapid and accurate determination of the varieties of Chinese medicine,only more efficient quality control method based on,in order to better ensure safe and effective medication.
Keywords/Search Tags:Shenkang Injection, medicine quality control, rhubarb, a more measured assessment
PDF Full Text Request
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