The Association Of Serum Glycated Apolipoprotein A-I With Revascularization Of Coronary Artery

Objective: To investigate whether glycation level of apolipoprotein A-I is associated with the revascularization of patients with coronary heart disease(CAD)after percutaneous coronary intervention(PCI).Methods: A total of 191 cases of CHD patients with secondary prevention after PCI were selected in the cardiology department of the sixth clinical hospital of Shanxi medical university from January 2016 to December 2017.According to the results of the CAG review,the experimental subjects were divided into the experimental group(24 cases)who needed coronary artery revascularization and no need of coronary artery revascularization as control group(167 cases).The baseline data,biochemical parameters and related risk factors of the two groups were collected and analyzed,and the influencing factors of coronary revascularization were analyzed statistically.The HDL was isolated and the correlation between the level of apo A-I glycation and the revascularization of coronary artery was analyzed by Western blot.Results: 1.Of the 191 patients with percutaneous coronary intervention,24 of the patients need coronary artery revascularization,account for 12.57%.2.Comparied between the two groups,the patients still smoking after PCI,dyslipidemia,diabetes,total cholesterol,fasting plasma glucose,2-h PG,Hb A1 c,multiple-vessel disease,the number of stent implantation and gly-apo A-I in the coronary artery revascularization group,which were higher than those in the control group,while HDL and apo A-I levels were lower than those in the control group.3.Spearman's rank-correlation test was used to analyze the influencing factors,the patients still smoking after PCI,dyslipidemia,multiple-vessel disease,diabetes and apo A-I glycation level are positively correlated with the coronary artery revascularization,while apo A-I is negatively correlated.4.Logistic regression analysis was conducted on the factors related to PCI,the patients still smoking after PCI,dyslipidemia,multiple-vessel disease,diabetes apo A-I glycation level are risk factors for coronary artery revascularization.while apo A-1 is a protective factor.5.In the experimental group and control group,the level of apo A-I glycation in patients with diabetes was higher than those without.In the patients with diabetes,the level of apo A-I glycation in the experimental group was higher than that in the control group.In patients not having diabetes,the level of apo A-I glycation in the experimental group was also higher than that in the control group.Conclusion: 1.In patients with coronary heart disease,smoking after PCI,poor lipid control,diabetes mellitus,multiple-vessel disease and higher apo A-I glycation level are more likely to cause coronary revascularization,while apo A-I is a protective factor for coronary revascularization.2.The level of apo A-I glycation can be used as a potential predictor for revascularization after percutaneous coronary intervention.3.The importance of secondary prevention medication in patients with coronary heart disease after PCI cannot be overemphasized,actively manage the level of plasma lipids and blood glucose levels,pay attention to the adjustment of life and dietary habits,quit smoking and low-fat diet.