Relationship Between Coronary Artery Lesion And Blood Glucose Among Coronary Artery Disease Patients With Normal Glycometabolism

Background:In recent years,many studies have found that in the probability of clinical cardiovascular events,patients with diabetes and non-diabetic patients with coronary heart disease are basically same,so the diabetes is no longer seen as a risk factor for coronary heart disease but come up with the concept of treating diabetes as a risk equivalent of coronary heart disease.Some studies have also confirmed that cardiovascular events have increased significantly in the early stages of diabetes.In patients with normal glucose metabolism,when the effect of blood glucose on coronary artery disease begins,and the effect of blood glucose and coronary artery disease remains to be further studied.Methods:In our research,we have collected basic clinical data and the levels of FPG,high density lipoprotein cholesterol(HDL-C),total triglycerides(TG),total cholesterol(CHO),low density lipoprotein cholesterol(LDL-C),glycosylated hemoglobin(Hb A1c)from1978 general patients whose chief complaint is chest discomfort.For further diagnosis,they are all confirmed by coronary angiography during their hospitalization.Results:Two independent samples of Wilcoxon signed rank test are performed to compare non-coronary artery disease group and coronary artery disease group,through this test we found that FPG,TG,SBP,DBP and age in coronary artery disease group are significantly higher than non-coronary artery disease group,and HDL-C is noticeably decreased,at the same time the proportion of smoking history and men in the coronary artery disease group are markedly increased.In addtion,multiple independent samples of Kruskal-Wallis H test result shows that FPG,CHO,SBP,DBP are increased,and HDL-C is decreased with the degree of coronary stenosis gained in the individuals with normal glucose metabolism.Meanwhile,in correlation analysis of each index,FPG,HDL-C,gender,age,smoking history,SBP have a significant impact on the dependent variable y whether the diagnosis is coronary heart disease.Conclusion This study indicates that FPG,SBP,age increased,HDL-C decreased,gender and smoking history are the risk factors for coronary artery disease.Tighter blood sugar control on the prevention and treatment of coronary artery disease is of great significance.