Chuzhen For Chronic Fatigue Syndrome At Acupoints Based On Eight-Trigram Theory Of Yi Jing :a Clinical Randomized Control Trial

Aim:To observe and evaluate the clinical efficacy of chuzhen for Chronic Fatigue Syndrome at acupoints based on Eight-trigram theory of Yi Jing or on Traditional Chinese acupuncture theory,and compare their differences.Findings would provide scientific evidence for treatment of Chronic Fatigue Syndrome using chuzhen at acupoints based on Eight-trigram theory.Methods:A randomized and controlled trial was designed.72 patients who matched the inclusion criteria were randomly divided into 2 groups.Each group was administered chuzhen puncturing at different acuponints : Group A: acupoints(DU20,LR3,KI1 and BL23)based on Eight-trigram theory of Yi Jing;Group B(DU24,PC6,SP6 and BL15)based on Traditional Chinese acupuncture theory.Both interventions were conducted by using chunzhen puncturing at these points respectively once per day,five days a week,and totally for 10 days.Krupp Fatigue Severity Scale(FSS)?Somatic and Psychological Health Report(SPHERE)and Medical Outcomes Survey Short Form-36(MOS SF-36)were used to evaluate the clinical efficacy before?right after the treatment,4 weeks follow-up.Results:(1)Baseline data: the baselines of the two groups showed no statistical differences(P>0.05).(2)Inner group comparison: The scores of FSS?SPHERE?MOS SF-36 for both Group A and Group B were significantly improved after treatment(P<0.01),and FAS analysis was consistent with PP analysis;The scores of FSS?SPHERE?MOS SF-36 for both Group A and Group B showed statistically significant difference before the treatment and on follow-up(P<0.01),and FAS analysis was consistent with PP analysis;Assessment of FSS?SPHERE?MOS SF-36 for both Group A and Group B on follow-up declined compared with that after treatment,showing statistically significant difference(P<0.01),and FAS analysis was consistent with PP analysis.(3)Inter group comparison:The improvements of FSS scores ?SPHERE scores?MOS SF-36 scores and clinical efficacy after treatment and on follow-up showed no statistical difference between Group A and Group B(P>0.05),and FAS analysis was consistent with PP analysis.Conclusion:1.Both acupoints based on Eight-trigram theory of Yi Jing or on Traditional acupuncture theory can be uesd to treat CFS.2.Chuzhen for Chronic Fatigue Syndrome at acupoints Based on Eight-trigram Theory of Yi Jing revealed a significant short-term clinical efficacy.Eight-trigram theory can be as a theoretical basis for acupoints selection for treatment of CFS.3.ChuZhen is a safe and effective means to improve CFS,with high adherence of subjects,which is worthy of attention and promotion.