Based On Sharing Systemthe Research For A Preliminary Study Of Diabetic Retinopathy Of TCM Syndrome Type And Core Prescription Rule

Purpose: Acquisition of chengdu university of traditional Chinese medicine hospital clinical scientific research information sharing system in diabetic retinopathy,diabetic retinopathy,DR)in hospitalized patients(disease information,establish a basic database,mining research DR risk factors and TCM syndrome type distribution and the regularity of prescription medication,for DR provide certain evidence of evidence-based clinical prevention and treatment of traditional Chinese medicine.Methods : Acquisition of chengdu university of traditional Chinese medicine hospital clinical scientific research information sharing system between 2013 and2016 cases of hospitalized patients with DR information into the standard of 256 cases.Personnel to export raw data sharing system by computer,in order to Excel save data(including basic information,the chief complaint,past medical history,personal history,engraving,physical and chemical indicators,signs,eye exam,four diagnostic information,diagnosis,prescription of traditional Chinese medicine,Chinese medicine,the doctor’s advice,etc.),and to inspect the database,orderly and standardized treatment.Using SPSS21.0 for age,sex,duration of diabetes,DR classification,such as descriptive statistics analysis,the duration of DM,blood glucose,blood lipid,renal function,blood pressure and the relationship between DR severity and correlation analysis.Use frequency and form than the research of TCM syndrome types and their distribution in patients with DR.Using the complex network system of traditional Chinese medicine(Liquorice software)of multilayer core network analysis,core of DR prescription of traditional Chinese medicine drugs,layered mining compatibility features and the regularity of drug use.Result:1.256 DR patients at an average age of 57.5 years,the biggest age was 80 years old,the minimum age of 38.Male,117 people,accounted for 46.4%,female,139 people,accounted for 54.3%.DM duration of 11.66 years on average,29 years,the longest shortest 0.4 years.DR2 level accounted for 2.73%,DR3 8.20%,DR4,DR5 accounted for 23.05% and 66.2%.256 cases of patients with hypertension disease,136 cases,68 merger of hyperlipidemia,merge coronary atherosclerosis sex 14 cases of heart disease,diabetes mellitus nephropathy(diabetic nephropathy,DN)31 cases,merger of 17 cases of cerebral infarction,merger diabetic peripheral neuropathy(diabetic peripheral neuropathy,DPN)22 cases.2.The correlation analysis results show that the relationship between DM course and DR illness severity by the Spearman rank correlation test,correlation coefficient= 0.013,p = 0.840 > 0.05,no linear correlation between the both.Fasting blood glucose,glycosylated hemoglobin,cholesterol,total cholesterol,TC),triglyceride(triglyceride,TG),high-density lipoprotein cholesterol(hdl-c)(high-densitylipoprotein cholesterol,HDL-C),low density lipoprotein(low densitylipoprotein cholesterol,LDL-C),urea nitrogen,serum creatinine,uric acid,systolic pressure,diastolic pressure and DR illness severity by Spearman inspection,Pearson correlation,P values were greater than 0.05,no statistical significance,fasting glucose,glycosylated hemoglobin,cholesterol,triglycerides,high-density lipoprotein cholesterol(hdl-c),low density lipoprotein cholesterol(hdl-c),blood urea nitrogen,creatinine,uric acid,systolic pressure,diastolic pressure and DR severity is no linear correlation.3.256 patients with DR documents appear for 25 cases,the number of cases(9.76%),two card combination cases of 133 cases,accounting for 51.95%,3 card combination cases of 96 cases,accounting for 37.5%,four card combination cases in2 cases,accounting for 0.78%.A single syndrome in 625,a single card type high frequency is: qi deficiency syndrome(48.00%),phlegm dampness syndromes(42.18%),Yin deficiency syndrome(33.45%),blood stasis(29.82%).Deficiency syndrome concentration distribution in men with qi deficiency syndrome(49.57%),Yin deficiency syndrome(29.06%),the empirical concentration distribution in phlegm dampness syndromes(47.00%),blood stasis(30.77%),deficiency syndrome also female patients with qi deficiency syndrome(52.52%),Yin deficiency syndrome(41.01%),the empirical with phlegm dampness syndromes(43.16%),blood stasis(31.65%),consistent with the overall card type distribution.Syndrome distribution between the different age groups,40 to 49,50 to 59,60-69 age group,70-79-year-old set of deficiency syndrome in patients with qi deficiency syndrome,Yin deficiency,the empirical with phlegm damp syndrome,blood stasis,consistent with the overall card type distribution,the difference is < 40 years old age group DR empirical concentration distribution in patients with qi depression syndrome(25.0%),80-89-year-old set of qi deficiency syndrome,Yin deficiency syndrome,blood deficiency,heat,phlegm dampness syndromes in the same frequency.Deficiencysyndrome type course < 1 year group focused on the deficiency of syndrome,Yin deficiency and Yang deficiency syndrome,the empirical focus on phlegm damp syndrome and blood stasis.Course in 1-5 years,6 to 10 years,11 to 15 years,16-20 years and more than 20 years of deficiency syndrome in patients with qi deficiency are concentrated in the syndrome,Yin deficiency,empirical focus on wet phlegm syndrome,blood stasis,consistent with the overall card type distribution,in particular,DM course < 1 years to 20 years in patients with deficiency syndrome is focused on the deficiency of syndrome,empirical focus on phlegm dampness syndromes,deficiency syndrome in patients with up to 20 years to focus on Yin deficiency syndrome,empirical focus to blood stasis.In DR card type distribution between the condition of different grading is also consistent with the overall card type distribution,in particular,DR2 level in patients with deficiency syndrome focuses on qi deficiency syndrome(71.43%),the empirical focus on phlegm dampness syndromes(71.43%).DR3 level in patients with deficiency syndrome in Yin deficiency syndrome(52.38%),the empirical focus on blood stasis(33.33%).DR4 level in patients with deficiency syndrome focuses on qi deficiency syndrome(49.15%),the empirical focus on phlegm dampness syndromes(40.68%).DR5 level in patients with deficiency syndrome focuses on qi deficiency syndrome(47.93%),the empirical focus on phlegm dampness syndromes(45.56%).4.The research involved treatment DR prescription 290 doses,traditional Chinese medicine(TCM)244,single taste traditional Chinese medicine(TCM)the cumulative frequency of usage,a total of 3826 times,high frequency of usage of drugs are: poria cocos,yam,astragalus,cogongrass rhizome,radix rehmanniae,ink dry lotus.In the network core taste of the first layer is: poria cocos,cattail pollen,yam,cogongrass rhizome,ink dry lotus,disappear,dodder,medlar,is the key ingredients in treatment of DR prescription,compatibility of poria cocos-yam highest frequency.At the core network layer 2 ingredients: angelica,turtle shell ginger,cinnamon,zhejiang fritillary,gun,aimed at and the compatibility of the main ingredients,including compatibility of turtle shell-cinnamon the highest frequency.Is at the core network layer 3 ingredients: salvia miltiorrhiza,alisma,coix seed,chrysanthemum,field thistle,is the compatibility of traditional Chinese medicine is commonly used for minor symptoms,including salvia miltiorrhiza compatibility-semen coicis highest frequency.Conclusion : 1.The fasting blood glucose,glycosylated hemoglobin,TC,TG,HDL-C,LDL-C,urea nitrogen,serum creatinine,uric acid,systolic pressure,diastolic pressure and DR no linear correlation relationship between disease severity.2.DR patients factors,the combination of common syndrome types are: qi deficiency card + phlegm dampness syndromes,deficiency of + Yin deficiency syndrome,qi deficiency syndrome,blood stasis and phlegm dampness syndrome,qi deficiency syndrome,Yin deficiency syndrome and phlegm dampness syndrome.3.DR mark love this virtual to real,this deficiency syndrome by qi deficiency syndrome,Yin deficiency is given priority to,the demonstration is given priority to with wet phlegm syndrome,blood stasis and phlegm dampness syndromes is the concentration of blood stasis syndrome.Phlegm dampness,blood stasis through DR different disease classification,different course of diseases,different age groups.4.DR the therapeutic principle is given priority to with qi and nourishing Yin,tonic liver and kidney,blood hemostasis.Soft firm fights,phlegm dehumidification is a core of therapeutic effective supplement.Spleen,nourishing blood hemostasis,qing with wet liver is added to the core principle of flexible.