Study On The Treatment Of Diabetic Nephropathy By Zhao Jinxi Based On Data Mining

Background:Diabetic kidney disease (DKD) is one of the most common chronic complications of diabetes. The prevalence of diabetes increased year by year. About 20～40% merger DKD got from diabetic patients. At present, about a third of the end-stage renal patients in our country are developed from diabetic kidney disease. However, In the European and American countries more than half of patients in end-stage renal disease are DKD. So far, its pathogenesis has not been fully elucidated and there is no effective method of prevention and treatment of DKD at home and abroad. Therefore, to explore effective methods to delay the progress of diabetic kidney disease has always been a hot spot of medical research. Clinical practices show that traditional Chinese medicine (TCM) prevention and treatment of DKD has certain advantages. So summarizing good effect experts about DKD clinical experience of diagnosis and treatment, has important theoretical significance and application value. It is also the precious wealth of TCM. Supervisor professor Zhao Jinxi has rich experiences in the diagnosis and treatment of DKD, and the treatment showed a significant clinical effect.Objective:Applicate data mining technology for exploratory research about the diagnosis and treatment DKD basis data made by Professor Zhao Jinxi. Conclude DKD characteristics of every period. Research Professor Zhao Jinxi academic point view in diabetic kidney disease syndrome distribution and pathogenesis of the evolution. Dig Zhao Jinxi’s medicine ideas for the treatment of diabetic kidney disease.Methods:Choose 120 DKD patients treated by Zhao Jinxi professor at Beijing university of Chinese medicine the first clinical hospital during September 2010-December 2015. Record all the data basis of the original information accurately into "basis data processing system", and preprocess those data in the "basis data processing system", import them in "the basis of traditional Chinese medicine database system", appliy general descriptive analysis、 frequency analysis、correlation analysis with other statistical data analysis, to get data mining results. Finally discuss the results and come to a conclusion.Results:1. By analysising DKD pathogenesis, the top ten pathogenesis in turn are:qi and Yin deficiency, blood stasis wet resistance, Yin and Yang deficiency, blood stasis into product, qi-blood deficiency, liver depression of hot, lift estrangement, and hot indicates, blood stasis TanNing deposition, heat injury fluid; further statistical different pathogenesis characteristics in stages. the early pathogenesis top five in turn:qi and Yin deficiency, blood stasis into product, liver depression of hot, blood stasis TanNing deposition, heat injury fluid. Middle of the top five pathogenesis in turn:qi and Yin deficiency, blood stasis wet resistance, liver depression of hot, blood stasis into product, Yin and Yang deficiency. The late top five pathogenesis:blood stasis wet resistance, deficiency of Yin and Yang, qi and blood deficiency, lift estrangement, and hot indicates; 2. Make statistics of DKD characteristics. It shows that more than 90% of the disease’s locations are kidney, lung and spleen. The site of DKD is slightly different in different stage:early in the lung and kidney, in the middle lung spleen kidney are related, at late mainly spleen and kidney; 3. In terms of DKD’s symptoms and signs, the frequency is taken in more than 40%:tongue dark, languid, faint, thirsty to drink more, turbid urine, nocturia more, lower limb swelling, defecate dry, and on the symptoms and signs are different in different periods, early in the majority with thirsty to drink more to visitors, in the middle with turbid urine and languid, at late lower limb swelling, languid, nocturia more frequency increased obviously; 4. Statistics of DKD syndrome distribution characteristic, take the frequency of over 20%, early in turn:qi and Yin deficiency syndrome, blood stasis into product syndrome, liver depression of hot syndrome, blood stasis TanNing syndrome. In the middle in turn:qi and Yin deficiency syndrome, blood stasis wet resistance syndrome, liver depression of heat syndrome, blood stasis into product syndrome, Yin and Yang deficiency syndrome. Terminal in turn:blood stasis wet resistance syndrome, Yin and Yang deficiency syndrome, qi and blood deficiency syndrome, lift estrangement syndromes, and hot indicates syndromes; 5. The most commonly used drug that Professor Zhao Jinxi treated DKD:astragalus membranaceus, salvia miltiorrhiza, angelica, pinellia tuber, rhizoma chuanxiong, glabrous greenbrier rhizome, orange peel, radix scutellariae, radix paeoniae alba, Bi Xie white, radix bupleuri, batryticated silkworm, cicada, kudzuvine root, tuckahoe, radix paeoniae rubra, turmeric, pyrrosia leaf, radix et rhizoma rhei, fructus arctii, winged euonymus twig, yam. Statistical characteristics of prescription drug efficacy, early is given priority to with qi and blood fights. On the basis of qi, blood, fights, mid attaches great importance to the dampness turbidity. Late is more emphasis on pure material discharge turbid poison, and stomach qi, protect kidney yuan; 6. Basis of prescription drug compatibility is commonly used in two groups, one group of astragalus, angelica, salvia miltiorrhiza, rhizoma ligustici wallichii four herbs with its compatibility from 70% to 90%. Another group is China root and Bi Xie, its compatibility rate above 90%.Conclusion:1. Professor Zhao Jinxi thinks diabetic kidney disease pathogenesis includes two aspects:virtual refers to qi and Yin deficiency, Yin and Yang deficiency. True mainly is qi stagnation, blood stasis, phlegm dampness, pathogenic heat, and many other pathological product. All the pathological products coalesced in renal collaterals, form the "mini remove lump". The micro remove lump formation is the core of the pathogenesis of the disease, but also should attach importance to qin and Yin deficiency; 2. Professor Zhao Jinxi advocats in the treatment of DKD staging classification of syndrome differentiation treatment. In clinical medicine, paid more attention to the qi and nourishing Yin, promoting blood circulation to remove blood stasis, fights disease elimination, drain turbidity detoxification drug applications. And he is good at drugs used in combination, such as radix astragali, radix angelicae sinensis, rhizoma ligustici wallichii, salvia miltiorrhiza and another group of drug glabrous greenbrier rhizome and Bi Xie; 3. Traditional Chinese Medical Basis Database System is flexible, diverse results stable work, to the traditional Chinese medicine famous old doctor’s inheritance provides a new method.