The Clinical Analysis Of The Status Epilepticus Presenting As New-onset Seizures In 223 Children

Objective:To analyze and summarize the etiology,imaging changes,and prognosis-related factors of the children with new-onset seizures presenting as status epilepticus.Prompt recognition and diagnostic the etiology to reduce the disability rate and mortality rate.Methods:A total of 223 children with SE who were first convulsed during the period from January 2014 to December 2016 in Shanxi Provincial Children's Hospital were selected and retrospectively collected clinical data related to the children.We summarized and summarized the etiology and imaging changes in children.All patients were divided into two groups according to Glasgow Outcome Score,favorable(5 points)and adverse outcome groups(1 to 4 scores).We eventually filter out statistically different prognostic factors(P<0.05).We used univariate and multivariate logistic regression models to determine adverse prognosis influencing factors in children with new-onset seizures presenting as status epilepticus.Results:1.223 cases were enrolled included in this study.There were 123 males and 100 females,with a male to female ratio of 1.23:1.This disease occurs throughout the year.And it often occurred in children under 2 years old.2.The most common etiologies for status epilepticus presenting as new-onset seizures were seizures,followed by the infection of central nervous system(28.7%)and prolonged febrile seizure(19.3%).3.Of the 223 study patients,urgent or emergent intracranial pathology accounted for 17.49% on neuroimaging.The result of univariate analysis showed that the age,convulsive duration,infection of central nervous system,fever(The temperature more than 38.0)were associated with the poor intracranial pathology.The older children of seizures may have higher rates of urgent or emergent pathology on neuroimaging.4.There were 187 cases(84.86%)with good prognosis and 36 cases(16.14%)in adverse group.Univariate analysis showed that age,duration of convulsions,central nervous system infection,and acute changes in imaging were significantly different among two groups(P<0.05).Logistic regression analysis showed that the age and central nervous system infections were independent risk factors of poor prognosis of children with new-onset seizures presenting as status epilepticus.Conclusions:The seizures presenting as status epilepticus occurred in children below 2 years old..The most common etiologies were seizures,followed by the infection of central nervous system(28.7%)and prolonged febrile seizure(19.3%).The age,convulsive duration,infection of central nervous system,fever(The temperature more than 38.0)were associated with the poor intracranial pathology of the neuroimaging.The older children of seizures may have higher rates of urgent or emergent pathology on neuroimaging.The age and central nervous system infections were independent risk factors of poor prognosis of children with new-onset seizures presenting as status epilepticus.