ApoEε4 Allele For Adults With Normal Cognitive Function Brain Microstructure Influence In Diffusion Kurtosis Imaging Research Study

Objective:Application of diffusion kurtosis tomography(DKI)magnetic resonance technology,comparison of brain microarchitectural differences between adults with normal cognitive function who carrying and non-carrying ApoEε4 allele,explore the age-related ApoEε4 alleles on its brain microstructure change and function,provide more functional imaging support for the early onset of AD pathogenesis and early prevention.Methods:Selected the group of young,middle-aged and elderly normal subjects 90 adults in all groups,take a test of the Mini-Mental State Scale(MMSE)to assess the subject’s cognitive function,collection and its line of ApoEε4 alleles of the detection of the oral mucosa,routine MRI scans and DKI scans were performed on subjects at the same time,scanning the measured bilateral frontal,parietal lobe,temporal lobe,corpus callosum,the value of the cingulate cortex and hippocampus after MK,MD value and FA value,using t test to each group in ApoEε4 alleles are carriers and noncarriers DKI parameters measured by difference comparison.To evaluate the significance of MK values、FA values and MD values difference between adults who carrying and non-carrying ApoEε4 with Multiple factor variance analysis.Results:1.For different age groups,ApoEε4 gene carriers in different parts of the carrier compared with non-carrier MK value,frontal lobe,temporal lobe and posterior cingulate gyrus not only affected by age,ApoEε4 gene alone,but also affected by the interaction between the two;The hippocampus is only affected by age-specific factors;the hippocampus is only affected by a single factor of the ApoEε4 gene.Compared with non-carriers,ApoEε4 gene carriers showed an increase in the MK value of the frontal lobe and gradually decreased until the old age was significantly lower than that of non-carriers2.For the FA values of different parts of the ApoEε4 gene carriers and non-carriers in different age groups,the corpus callosum was affected not only by age and ApoEε4 gene,but also by the interaction between the two;the frontal and posterior cingulate gyrus Affected only by a single age factor;the hippocampus is affected by both age and the ApoEε4 gene alone,but is not affected by the interaction between the two3.For the different parts of the ApoE ε4 gene carriers and non-carriers in different age groups,compared with the MD value of the different parts of the body,the corpus callosum was only affected by the age single factor.Conclusion:1.The multiple parameters of DKI can reflect the changes of brain microcosmic structure of ApoEε4 carriers in different age groups,and can provide certain functional imaging support for early onset evolutionary mechanism and early prevention of AD.2.Changes in the function of the frontal lobe,temporal lobe,and posterior cingulate gyrus are not only affected by age and the ApoE ε4 gene alone,but also affected by the interaction between the two;Relative to the non-carriers of the gene,the functional changes of the frontal microcosmic structure of the ApoEε4 gene carrier showed compensatory weakening after compensatory enhancement,leading to a decrease in frontal lobe function.3.The decline of hippocampal function is affected by ApoEε4 gene earlier,and the decline of temporal lobe function is affected by ApoEε4 gene later;the function of hippocampus is only affected by single factor of ApoEε4 gene...